| NEGATIVE EFFECTS OF ETHANOL ON ISOLATED GUINEA PIG LEFT ATRIUM AND PAPILLARY MUSCLES |
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| 作者姓名： | 胡浩 臧伟进 于晓江 王昌利 张凤杰 孙强 张春虹 |
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| 作者单位： | Hu Hao，Zang Weijin，Yu Xiaojiang，Wang Changli，Zhang Fengjie，Sun Qiang，Zhang ChunhongDepartment of Pharmacology，Medical School of Xi'an Jiaotong University，Xi'an 710061，China. |
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| 基金项目： | ThisresearchwassupportedbytheNationalNaturalScienceFoundationofChina (No .39870 334，No .39970 2 73) ,theHighEducationalSpecialResearchFoundationforDoctorialSubject (No.2 0 0 10 6 980 34)andKeyItemofScientificTechnologyforMinistryofEducation (No .0 116 1) |
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| 摘 要： | Ｅｔｈａｎｏｌｉｓｗｉｄｅｌｙｃｏｎｓｕｍｅｄｉｎｔｈｅｗｏｒｌｄａｓａｋｉｎｄｏｆｃｏｍｍｏｎｄｒｉｎｋａｎｄｄｒｕｇｉｎｏｕｒｌｉｆｅ .Ｔｈｅｓｔｕｄｙｏｆｅｔｈａｎｏｌｉｓｖｅｒｙｉｍｐｏｒｔａｎｔｆｏｒｈｕｍａｎ’ｓｈｅａｌｔｈ ,ｅｓｐｅｃｉａｌｌｙ ,ｍｏｒｅａｎｄｍｏｒｅｒｅｓｅａｒｃｈｅｓｐａｙａｔｔｅｎｔｉｏｎｔｏｔｈｅｅｆｆｅｃｔｓｏｆｅｔｈａｎｏｌｏｎｃａｒｄｉｏｖａｓｃｕｌａｒｓｙｓｔｅｍ .Ｈｏｗｅｖｅｒ,ｔｈｅｍｅｃｈａｎｉｓｍｂｙｗｈｉｃｈｅｔｈａｎｏｌｉｎｄｕｃｅｓｔｈ…
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NEGATIVE EFFECTS OF ETHANOL ON ISOLATED GUINEA PIG LEFT ATRIUM AND PAPILLARY MUSCLES |
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| Hu Hao,Zang Weijin,Yu Xiaojiang,Wang Changli,Zhang Fengjie,Sun Qiang,Zhang Chunhong.NEGATIVE EFFECTS OF ETHANOL ON ISOLATED GUINEA PIG LEFT ATRIUM AND PAPILLARY MUSCLES[J].Academic Journal of Xi’an Jiaotong University,2002,14(1). |
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| Authors: | Hu Hao Zang Weijin Yu Xiaojiang Wang Changli Zhang Fengjie Sun Qiang Zhang Chunhong |
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| Institution: | Department of Pharmacology, Medical School of Xi'an Jiaotong Universit y, Xi'an 710061,China. |
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| Abstract: | Objective To investigate the effects of ethanol on physiologic al characteristics of the isolated guinea pig left atrium and papillary muscles.Methods The effects of ethanol on contractility, post-rest potentiatio n and positive staircase phenomenon were observed in isolated left atrium and pa pillary muscles of guinea pig.Results Ethanol(50.0,100.0,200.0mmol*L-1)prominently inhibited the con traction of papillary muscles. Ethanol(12.5,25.0,50.0,100.0,200.0mmol*L-1 ) inhibited the contraction of left atrium, and markedly decreased the post-r est potentiation of myocardial contractility in left atrium. High concentration of ethanol(100,200mmol*L-1) depressed the positive staircase phenomenon of isolated guinea pig left atrium.Conclusion These results suggest that ethanol induces inhibitor y effects of the contractility, post-rest potentiation, positive staircase phen omenon of left atrium. The mechanism by which ethanol induces the negative inotr opic effects may be related to decrease the amount of calcium released from the intracellular stores. |
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| Keywords: | ethanol left atrium papillary muscles contractility post-rest potentiation |
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