| TERATOGENIC EFFECT OF ANTI-HBs-A CONCURRENT COHORT STUDY |
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| 作者姓名： | 岳亚飞 张树林 门伯媛 李义方 陈太平 吴玲 |
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| 摘 要： | ＴＥＲＡＴＯＧＥＮＩＣＥＦＦＥＣＴＯＦＡＮＴＩ－ＨＢｓ－ＡＣＯＮＣＵＲＲＥＮＴＣＯＨＯＲＴＳＴＵＤＹＹｕｅＹａｆｅｉ；ＺｈａｎｇＳｈｕｌｉｎ；ＭｅｎＢｏｙｕａｎ；ＬｉＹｉｆａｎｇ；ＣｈｅｎＴａｉｐｉｎｇ；ＷｕＬｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＯｂｓｔ...
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TERATOGENIC EFFECT OF ANTI-HBs-A CONCURRENT COHORT STUDY |
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| Yue Yafei, Zhang Shulin, Men Boyuan,Li Yifang, Chen Taiping, Wu Ling.TERATOGENIC EFFECT OF ANTI-HBs-A CONCURRENT COHORT STUDY[J].Academic Journal of Xi’an Jiaotong University,1994(1). |
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| Authors: | Yue Yafei Zhang Shulin Men Boyuan Li Yifang Chen Taiping Wu Ling |
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| Abstract: | One thousand, five hundred and seventy six pregnant women were followed upprospectively from early pregnancy to investigate the relation or Anti-HBs and other 10 risk factors from pregnant women with the congenital malformation of newborn. The results confirmed the teratogenic effect of Anti-HBs. The monofactorial analysis showed that the newborn congenital malformationincidence in Anti-HBs positive mothers was higher than that in Anti-HBs negative mothers (x2=6. 0274,P = 0.0141). The multifactorial analysis by using unconditional Logistic Repression model confirmed that Anti-HBs had a teratogenic effect (OR=5. 30952, P=0. 000302). The possibleteratogenic mechanism of Anti-HBs is discussed. It is important to further study the teratogenic effect of Anti-HBs in eugenics. Anti-HBc may have prevention effect on congenital malformation development (OR= 0. 27110, P= 0. 004515). In addition, exposure to toxicants during pregnancy is one of the risk factors causing congenital malformation (OR= 8. 17080, P=0. 001780). |
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| Keywords: | HBsAg Anti-HBs Anti-HBc congenital malformation toxicant |
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