| DETECTION OF CYTOMEGALOVIRUS（CMV） IMMEDIATE EARLY ANTIGENIN KIDNEY BIOPSIES AND TRANSPLANT NEPHRECTOMIES |
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| 引用本文： | 燕航,薛武军,田普训,郭奇,何晓丽.DETECTION OF CYTOMEGALOVIRUS（CMV） IMMEDIATE EARLY ANTIGENIN KIDNEY BIOPSIES AND TRANSPLANT NEPHRECTOMIES[J].西安交通大学学报(英文版),2004,16(1):88-91. |
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| 作者姓名： | 燕航 薛武军 田普训 郭奇 何晓丽 |
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| 作者单位： | Department of Renal Transplantation，Department of Renal Transplantation，Department of Renal Transplantation，Department of Renal Transplantation，Department of Renal Transplantation First Hospital of Xi’an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Cytomegalovirus (CMV )infectionisoneofthemostcommonposttransplantcomplicationsandwasassociatedwithanincreasedmorbidityandmor talityintransplantrecipients1,2 ] .Duringthefirst 4monthsafterrenaltransplantation ,theincidenceofactiveCMVinfectionisapproximately 5 0 % -90 % 3] .Recently ,manyresearchershavefoundthatCMVcouldaffecttheimmunityofhumanbe ing .CMVinfectionisalsoariskfactorforacuteandchronicrejectionofrenalallograftanddirectlycorrelateswithdecreased patientandallograftsur vival4 - 7…
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| 关 键 词： | 细胞巨化病毒 肾脏移植 免疫组织化学 直接抗原 肾脏组织 |
DETECTION OF CYTOMEGALOVIRUS(CMV) IMMEDIATE EARLY ANTIGEN IN KIDNEY BIOPSIES AND TRANSPLANT NEPHRECTOMIES |
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| Abstract: | Objective To investigate the relationship between CMV infection and renal allograft rejection. Methods 39 kidney biopsies and transplant nephrectomies were collected and investigated for CMV immediate early antigen by immunohistochemistry. Results In 14 out of 39 tissue specimens CMV immediate early antigen were found. 8 biopsies from normal donor kidneys were negative; only 1 (10%) in 10 tissue specimens with early stage acute rejection was positive; 5(55.6%) in 9 biopsies with late stage acute rejection and 8 (66.7%) in 12 tissue blocks with chronic rejection were positive. Compared with normal kidney tissues, the infections in tissues with early stage acute rejection didn't increase obviously, but increased obviously in kidney tissue specimens with late stage rejection and with chronic rejection (P< 0.05). Conclusion CMV infection appears to contribute to late stage acute rejection and chronic rejection after renal transplantation. |
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| Keywords: | renal transplantation cytomegalovirus immunohistochemistry immediate early antigen allograft rejection |
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