| EXPRESSION OF NESTIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PERIOD AFTER SPINAL INJURY IN ADULT RATS |
| |
| 作者姓名： | 屈建强 贺西京 杨平林 师蔚 李浩鹏 兰宾尚 袁普卫 王国毓 |
| |
| 作者单位： | [1]DepartmentofNeurosurgery,SecondHospitalofXi＇anJiaotongUniversity,Xi＇an710004,China [2]SecondDepartmentofOrthopaedics,SecondHospitalofXi＇anJiaotongUniversity,Xi＇an710004,China, [3]DepartmentofNeurosurgery,SecondHospitalofXi＇anJiaotongUniversity,Xi＇an710004,China |
| |
| 基金项目： | ThisworkwassurpportedbytheNaturalScienceFoundationofChina(No.30371442) |
| |
| 摘 要： | Objective To study the expression of Nestin and glial fibrillary acidic protein (GFAP) in different period after spinal injury in adult rats. Methods Animal moels were created by artery clamp. Expression of Nestin and GFAP in different period ( 1,3,5days; 1-8 weeks) and different area( injury locus and its surrounding tissue ) after spinal injury were observed pathologicaly using immunofluorescence and LeicaQ5001W imaging processing system.Results There was expression of Nestin and GFAP in injured area 1 day after injury. The expression increased not only in in injured area but its sourrounding 3--7 days later and gradually got to peak value. As the time went on, expression of Nestin and GFAP dereased. Conclusion Spinal injury can induce the expression of Nestin. Nerve stem cell has response to spinal injury. There is positive correlation between expression of Nestin and hyperplasia of reactivity astrocyte. Nerve stem cell maybe invovled in the repair of central nervous system (CNS).
|
| 关 键 词： | 脊髓损伤 免疫萤光 GFAP 酸性蛋白 |
EXPRESSION OF NESTIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PERIOD AFTER SPINAL INJURY IN ADULT RATS |
| |
| Qu Jianqiang,He Xijing,Yang Pinglin,Shi Wei,Li Haopeng,Lan Binshang,Yuan Weipu,Wang Guoyu.EXPRESSION OF NESTIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PERIOD AFTER SPINAL INJURY IN ADULT RATS[J].Academic Journal of Xi’an Jiaotong University,2004,16(2):184-187. |
| |
| Authors: | Qu Jianqiang He Xijing Yang Pinglin Shi Wei Li Haopeng Lan Binshang Yuan Weipu Wang Guoyu |
| |
| Institution: | 1. Department of Neurosurgery,Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
2. Second Department of Orthopaedics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China. |
| |
| Abstract: | Objective To study the ex pr ession of Nestin and glial fibrillary acidic protein (GFAP) in different period after spinal injury in adult rats. Methods Animal moels were cr eated by artery clamp. Expression of Nestin and GFAP in different period (1,3,5d ays;1-8 weeks) and different area(injury locus and its surrounding tissue ) afte r spinal injury were observed pathologicaly using immunofluorescence and LeicaQ5 00IW imaging processing system. Results There was expression of Nestin and GFAP in injured area 1 day after injury.The expression increased not only in in injured area but its sourrounding 3-7 days later and gradually got t o peak value. As the time went on, expression of Nestin and GFAP dereased. Conclusion Spinal injury can induce the expression of Nestin. Nerve stem cell has response to spinal injury. There is positive correlation between e xpression of Nestin and hyperplasia of reactivity astrocyte. Nerve stem cell may be invovled in the repair of central nervous system (CNS). |
| |
| Keywords: | spinal injury immunofluorescence Nestin glial fibrillary acidic protein (GFAP) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
