| Correlation between endothelia cells activation and imbalance of cytokines in pulmonary hypertension of congenital heart disease |
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| 作者姓名： | Lü Yi |
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| 作者单位： | Department of Cardiovascular Surgery, the First Affiliated Hospital, Medical School of Xi＇anJiaotong University, Xi＇an 710061, China |
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| 基金项目： | this work was supported by Xi＇an Science and technology Research Fund （GG04134）. |
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| 摘 要： | Objective To explore the correlation between endothelia cells activation and cytokines （ET-1, NO） levels in patients with pulmonary hypertension （PH）, and to discuss their roles in the development of PH. Methods Twenty patients with simple ventricular septal defect （VSD） were chosen as controls, and 30 patients with PH were studied. Plasma levels of ET-1 and NO were measured by radioimmunoassay or colorimetric method. Before cardiopulmonary bypass was established, the specimens from right lung were fixed with formaldehyde solution, embedded with paraffin and stained by SP immunohlstochemistry. Intercellular adhesion molecule-1 （ICAM-1） expression was measured through the determination of the light density with computer imaging technology. Results Compared with that of the patients with simple VSD, the light density of ICAM-1 and plasma level of ET-1 increased in patients with PH; but plasma level of NO decreased （P〈0.05）. Positive correlation was observed between ICAM-1 and ET-1/NO （P〈0.05）. Conclusion Endothelia cells activation and imbalance of ET-1/NO might play an important role in the development of PH.
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| 关 键 词： | 先天性心脏病 肺高血压 内皮细胞 细胞间支持因子-1 一氧化氮 |
| 文章编号： | 1671-8267（2007）02-0208-04 |
Correlation between endothelia cells activation and imbalance of cytokines in pulmonary hypertension of congenital heart disease |
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| Shi Tao,Lü Yi,Geng Xigang,Li Zhaozhi.Correlation between endothelia cells activation and imbalance of cytokines in pulmonary hypertension of congenital heart disease[J].Academic Journal of Xi’an Jiaotong University,2007,19(2):208-211. |
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| Authors: | Shi Tao Lü Yi Geng Xigang Li Zhaozhi |
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| Abstract: | Objective To explore the correlation between endothelia cells activation and cytokines (ET-1, NO) levels in patients with pulmonary hypertension (PH), and to discuss their roles in the development of PH. Methods Twenty patients with simple ventricular septal defect (VSD) were chosen as controls, and 30 patients with PH were studied. Plasma levels of ET-1 and NO were measured by radioimmunoassay or colorimetric method. Before cardiopulmonary bypass was established, the specimens from right lung were fixed with formaldehyde solution, embedded with paraffin and stained by SP immunohistochemistry. Intercellular adhesion molecule-1 (ICAM-1) expression was measured through the determination of the light density with computer imaging technology. Results Compared with that of the patients with simple VSD, the light density of ICAM-1 and plasma level of ET-1 increased in patients with PH; but plasma level of NO decreased (P<0.05). Positive correlation was observed between ICAM-1 and ET-1/NO (P<0.05). Conclusion Endothelia cells activation and imbalance of ET-1/NO might play an important role in the development of PH. |
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| Keywords: | congenital heart disease (CHD) pulmonary hypertension (PH) endothelia cells activation intercellular adhesion molecule-1 (ICAM-1) nitric oxide (NO) endothlin-1 (ET-1) |
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