| EXPRESSION AND SIGNIFICANCE OF BASIC FIBROBLAST GWOWTH FACTOR AND FIBROBLAST GROWTH FACTOR RECEPTOR-1 IN OVARIAN EPITHELIAL NEOPLASM |
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| 作者姓名： | 高尚风 杨蓉 高博 刘惠喜 |
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| 作者单位： | Department of Obstetrics and Gynecology，Department of Obstetrics and Gynecology，Department of Obstetrics and Gynecology，Department of Obstetrics and Gynecology First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Basicfibroblastgrowedfactor (bFGF)wasakindofmultifunctionalgrowthfactorwhichhadahighaffcinitywithitsmainreceptorwhosenamewasfibroblastgrowthfactorreceptor 1(FGFR 1) .ByFGFRsuchasFGFR 1,bFGFcouldnotonlyin ductthegrowthofnewcapillary ,butalsostimulatethecell’smitokasisandpropagationaspowerfulmi tosigen ;Bystimulatingendothelialandtumorcelltosynthesizetheprofibrnolysinactivator(uPA ) ,re leasefibrinaseandcollagenase ,synthesizecollage nase ,sotoenhencetumorcell’sabilitytoinvadeentracell…
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EXPRESSION AND SIGNIFICANCE OF BASIC FIBROBLAST GWOWTH FACTOR AND FIBROBLAST GROWTH FACTOR RECEPTOR-1 IN OVARIAN EPITHELIAL NEOPLASM |
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| Gao Shangfeng,Yang Rong,Gao Bo,Liu Huixi.EXPRESSION AND SIGNIFICANCE OF BASIC FIBROBLAST GWOWTH FACTOR AND FIBROBLAST GROWTH FACTOR RECEPTOR-1 IN OVARIAN EPITHELIAL NEOPLASM[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
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| Authors: | Gao Shangfeng Yang Rong Gao Bo Liu Huixi |
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| Institution: | Department of Obstetrics and Gynecology, First Hospital of Xi'an Jiaotong University, Xi'an 710061,China |
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| Abstract: | Objective To study the relevance of expression of basic fibroblast growth factor (bFGF), fibroblast growth factor receptor 1 (FGFR 1) and carcinogenesis and progression of ovarian epithelial neoplasm. Methods Ten cases of normal ovarian tissues and 75 cases of ovarian epithelial neoplasm tissues were detected by immunohistochemical methods: S P for bFGF, FGFR 1,double immunohistochemistry Lab SA for Ki 67 antigen and bFGF. Results The expression level of bFGF, FGFR 1in ovarian epithelium and ovarian epithelial neoplasm showed a step wise increase in the following order:normal
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| Keywords: | basic fibroblast growth factor (bFGF) fibroblast growth factor receptor 1 (FGFR 1) Ki 67 antigen ovarian epithelial neoplasm |
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