| DIAGNOSTIC VALUE OF SERUM PROGRP31-98 IN PATIENTS WITH SMALL-CELL LUNG CANCER |
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| 作者姓名： | 李昂 杨谨 李旭 李蓉 王一理 司履生 |
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| 作者单位： | Institute for Cancer Research，Department of Medical Oncology，Institute for Cancer Research，Department of Medical Oncology，Institute for Cancer Research，Institute for Cancer Research School of Life Science & Technology，Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi’an710061，China，School of Life Science & Technology，Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi’an Jiaotong University，Xi’an710061，China，School of Life Science & Technology，Xi'an Jiaotong University，Xi'an 710061，China，School of Life Science & Technology，Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Small celllungcancer (SCLC )isasubtyperepresentingapproximately 15 %to 2 0 %ofallpri marylungcarcinomaoccurringinChina .Ingener al,SCLCishighlysensitivetochemotherapyandhasafrequenttendencytometastasizeatanearlystage .Thus ,itisveryimportanttomakeanearlydiagnosisforthetreatmentofSCLC patients .NSEhaslongtermbeenusedasSCLCearlydiagnosismarkerinclinic1] .However ,therelativelyhighfalse positiveratehasforcedthedoctorstolookforthemorespecificandsensitivemarker2 ] .SincePro gastrin relea…
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DIAGNOSTIC VALUE OF SERUM PROGRP31-98 IN PATIENTS WITH SMALL-CELL LUNG CANCER |
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| Abstract: | Objective To explore the clinical significance of serum level of pro-gastrin-releasing peptide 31-98 (ProGRP31-98) for small-cell lung cancer (SCLC), in comparison with neuron-specific enolase (NSE). Methods Serum level of ProGRP31-98 and NSE was measured by ELISA respectively in 30 patients with SCLC, 30 with non-small cell lung cancer (NSCLC), 15 with benign lung diseases and 15 normal subjects, additionally, 10 SCLC patients after having treatment with chemotherapy were included. The receiver operating characteristic (ROC) curve was used to set the cut-off value and evaluate the diagnostic accuracy. Results The serum level of ProGRP31-98 was higher in patients with SCLC than that in other groups. The SCLC patients with extensive disease had a higher value than the patients with limited disease. In SCLC patients with distant metastases, it was also higher than in those without. Increase in serum ProGRP31-98 and NSE was both seen in SCLC patients, but for the former one, the increase was of much greater compared to the normal controls. Given the cut-off value for ProGRP31-98 was 40ng*L-1 and for NSE 8μg*L-1, their sensitivity of diagnosis in SCLC was 73% and 60%, respectively. The area under ROC curve of ProGRP31-98 was significantly larger than that of NSE. All patients responded to chemotherapy showed marked decrease in ProGRP31-98. Conclusion ProGRP31-98 is a more specific and sensitive marker than NSE in the diagnosis of SCLC. |
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| Keywords: | lung neoplasms small cell lung cancer proGRP31 98 tumor marker |
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