| EFECT OF ERYTHROMYCIN ON INTERDIGESTIVE MIGRATING MOTOR COMPLEX IN HUMANS |
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| 作者姓名： | 赵平 董蕾 兰康 徐尔迪 戴菲 罗金燕 龚均 |
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| 作者单位： | Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China，Department of Gastroenterology，Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China |
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| 基金项目： | ThisresearchwassupportedbytheNationalNaturalScienceFoundationofChina(No.30170414). |
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| 摘 要： | Erythromycin(EM),amacrolideantibiotic,is widelyusedintreatingmanyinfectiousdiseases.Administrationofthisdrugeitherorallyorintrave nouslyiscapableofcausinggastrointestinalside effects,suchasnausea,vomiting.Ithasbeenrepor tedrecentlythatEMhadstimulatoryfunc…
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| 关 键 词： | 抗生素 大环内酯物 药物 EM 人体健康 |
| 文章编号： | 1671-8267（2005）02-0141-04 |
EFECT OF ERYTHROMYCIN ON INTERDIGESTIVE MIGRATING MOTOR COMPLEX IN HUMANS |
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| Zhao Ping;Dong Lei;Lan Kang;Xu ErDi;Dai Fei;Luo JinYan;Gong Jun.EFECT OF ERYTHROMYCIN ON INTERDIGESTIVE MIGRATING MOTOR COMPLEX IN HUMANS[J].Academic Journal of Xi’an Jiaotong University,2005,17(2):141-144. |
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| Authors: | Zhao Ping;Dong Lei;Lan Kang;Xu ErDi;Dai Fei;Luo JinYan;Gong Jun |
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| Abstract: | Objective To investigate the effect of erythromycin (EM) on interdigestive migrating motor complex (MMC) in healthy volunteers. Methods 20 healthy volunteers were randomly divided into 2 groups: EM group (n=11) and placebo group (n=9). The changes of MMC were observed by gastrointestinal manometry before and after oral administration of EM or placebo. Results Gastric antral MMCs that evoked by EM were similar to spontaneous MMCs. EM orally intaking decreased MMC cycle duration significantly (P<0.05). EM orally intaking decreased the percentage of phase Ⅱ duration to MMC cycle duration significantly (P<0.05). But EM orally intaking increased the percentage of phase Ⅲ duration to MMC cycle duration significantly (P<0.05). The amplitude of antral waves of phase Ⅲ increased significantly after EM orally intaking (P<0.05). Placebo orally and percentages of phase Ⅰ, phase Ⅱ, phase Ⅲ duration to MMC cycle duration. Conclusion EM has stimulating effect on gastrointestinal motor activity. |
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| Keywords: | migrating motor complex erythromycin gastrointestinal manometry |
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