Histologic changes in the sinus membrane after maxillary sinus augmentation with simultaneous implant placement using engineered bone graft material |
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| Authors: | Jia-Yu Lu Wei Zhao Hong Zhu Xiao-Hui Qu and De-Rong Zou |
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| Institution: | (1) Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People’s Republic of China;(2) Oral Bioengineering Lab, Shanghai Research Institute of Stomatology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, 200011, People’s Republic of China;(3) Department of Oral Maxillofacial Surgery, Affiliated Hospital of Ningxia Medical University, Ningxia, 750004, People’s Republic of China;(4) Department of Prosthodontics, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People’s Republic of China; |
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| Abstract: | The aim of the study was to analyze the histologic and ultrastructural changes after maxillary sinus augmentation with simultaneous
implant placement using engineered bone graft material. In this study, calcium phosphate cement (CPC) scaffolds combined with
goat bone marrow stromal cells (BMSCs) were used to fill goat sinus floor space after maxillary sinus floor elevation with
simultaneous implant placement comparing with those not filled any grafted materials and used as controls. After a healing
period of 3 months, the goat maxillary sinus membrane was examined using light microscopy and scanning electronic microscopy.
The results showed that the connective tissue thickness and the epithelium thickness of mucosa were not statistically significant
difference between two groups. The tissue engineered bone complex might be an ideal graft for the sinus floor elevation and
have no influence on the sinus membrane under the histological and ultrastructural observation. |
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