| 海洋真菌抗表皮葡萄球菌抗生素的初步研究 |
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| 引用本文： | 张翼,穆军,阎松,顾晓洁,谷朋娟,陈明,徐亚周,李赫男.海洋真菌抗表皮葡萄球菌抗生素的初步研究[J].大连铁道学院学报,2010(2):46-50. |
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| 作者姓名： | 张翼 穆军 阎松 顾晓洁 谷朋娟 陈明 徐亚周 李赫男 |
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| 作者单位： | 大连交通大学环境与化学工程学院; |
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| 基金项目： | 国家863计划资助项目(2006AA09Z426); 国家自然科学基金资助项目(20902009); 大连市优秀青年科技人才基金资助项目(2008J23JH041) |
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| 摘 要： | 从海藻和海绵表面或组织内分离筛选出五株具有抑制表皮葡萄球菌活性的海洋真菌,分别鉴定为木霉属、光孢青霉、曲霉属、尖孢镰刀霉和交链格孢霉.经单剂量法测定其每毫升发酵液抑制表皮葡萄球菌的效价分别相当于氨苄青霉素0.8单位、1.1单位、22.5单位、7.9单位和6.2单位.高效液相色谱分析显示这五株真菌的代谢产物具有较显著差异,抗菌活性生物自显影表明这些菌株的抗表皮葡萄球菌抗生素成分也呈现较高的多样性.化学显色试验表明其中一株曲霉菌DLEP2008001的最强活性成分可能为含有仲胺及羧基基团的甾体或三萜类化合物,而次强活性成分可能为含有仲胺基团的化合物.研究结果表明,作为抗表皮葡萄球菌后备药物的潜在来源,海洋真菌值得深入研究.
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| 关 键 词： | 海洋真菌 抗生素 表皮葡萄球菌 |
Initial Research on Anti-Staphylococcus epidermidis Antibiotics from Marine Fungi |
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| ZHANG Yi,MU Jun,YAN Song,GU Xiao-jie,GU Peng-juan,CHEN Ming,XU Ya-zhou,LI He-nan.Initial Research on Anti-Staphylococcus epidermidis Antibiotics from Marine Fungi[J].Journal of Dalian Railway Institute,2010(2):46-50. |
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| Authors: | ZHANG Yi MU Jun YAN Song GU Xiao-jie GU Peng-juan CHEN Ming XU Ya-zhou LI He-nan |
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| Institution: | ZHANG Yi,MU Jun,YAN Song,GU Xiao-jie,GU Peng-juan,CHEN Ming,XU Ya-zhou,LI He-nan(School of Environmental , Chemical Engineering,Dalian Jiaotong University,Dalian 116028,China) |
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| Abstract: | Five marine fungi isolated from the surface or inner tissue of marine algae and sponge show inhibitory activity against Staphylococcus epidermidis.They were identified as Trichoderma sp.,Penicillium glabrum,Aspergillus sp.,Fusarium oxysporum and Alternaria alternata.By single dosage method,the antibacterial titers of their ferment broths are determined to be equal to 0.8,1.1,22.5,7.9 and 6.2U/mL of ampicillin,respectively.HPLC analysis shows that the products of these five fungi are remarkably different.The... |
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| Keywords: | marine fungi antibiotics Staphylococcus epidermidis |
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