| 被动吸烟对小鼠致突变作用 |
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| 引用本文： | 李义平,王亚文,张振军,王治平,张俊伟.被动吸烟对小鼠致突变作用[J].西安交通大学学报(医学版),2002,23(2):141-143. |
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| 作者姓名： | 李义平 王亚文 张振军 王治平 张俊伟 |
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| 作者单位： | 1. 西安交通大学,医学院公共卫生学系环境卫生学教研室,西安,71006
2. 西安交通大学,第一医院检验科,西安,710061 |
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| 摘 要： | 目的 确定被动吸烟对小鼠的遗传毒性效应。方法 应用实验动物模型 ,小鼠骨髓嗜多染红细胞微核试验和精子畸形试验。结果 被动吸烟组小鼠骨髓嗜多染红细胞微核率和精子畸形率高于阴性对照组 ,差异均有显著性 (P <0 .0 5 ) ,被动吸烟组的精子畸形率与染毒剂量成良好的量效关系 (r=0 .995 0 ,P <0 .0 5 )。结论 提示被动吸烟可在小鼠骨髓嗜多染红细胞微核试验和精子畸形试验中 ,对小鼠产生致突变作用
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| 关 键 词： | 被动吸烟 侧流烟雾 遗传毒性 微核 精子畸形 |
| 文章编号： | 0258-0659(2002)02-0141-03 |
| 修稿时间： | 2000年11月15 |
Effects of passive smoking mutagenesis on Wistar mice |
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| Abstract: | Objective To explore the genotoxicity of passive smoking in Wistar mice. Methods Micronuclear test in polychromatic erythrocytes (PCEs) of bone marrow and sperm abnormality test in Wistar mice were performed. Results The sperm abnormality rate and the micronuclear rate in passive smoking groups were significantly higher than those in negative controls ( P < 0.05 ).Sperm abnormality test showed dose response relationship between the sperm abnormality rate in passive smoking group and dosage ( r= 0.9950 ,P < 0.05 ).Conclusion Passive smoking not only affects body cells, but also hurts sperms, reproductive cells. Therefore, passive smoking has strong mutagenesis. |
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| Keywords: | passive smoking side stream genotoxicity micronuclear sperm abnormality |
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