1046例围产儿尸检病理分析的临床与优生意义

１９８５年１２月～１９９０年１２月底监测围产儿１５３８８１例，死亡３９５５例，尸检１０４６例，检出畸形５６７例，占５４．２１％，居首位。其次胎儿缺氧、肺炎、颅内出血２６３例（２５．１４％）及妊娠合并症１５４例（１４．７２％）。畸形中检出单纯内脏畸形２２８例（占尸检的２１．８％），以心脏畸形７３例（３２．０２％）最多。体表合并内脏畸形１６８例中以肾畸形５６例（３３．３３％）最多。有５３６例靠尸检证实死亡的原因或检出有关的遗传因素，为进一步产前诊断和优生咨询提供依据。

CLINICAL AND EUGENIC SIGNIFICANCE OF AUTOPSY PATHOLOGIC ANALYSIS OF 1046 PERINATAL NEWBORNS

From December 1985 to December 1990,153881 perinatal newborns were surveyed,of the 3955 cases were dead and 1046 cases underwent autopsy 567 of 1046 autopsies (54.21%)were malformed.Other causes included fetal anoxia,pneumonia,intracranial hemorrhage(25. 14%)(26 3 cases)and 154 cases of complication of pregnancy( 14.72%). 228 of 567 malformed cases (21.8%)were single internal organ deformities. 73of 228 cases (32. 02%)were heart deformities, with the highest ratio. 56 of 168 external and internal organ deformities were complicated by kidney deformities(33.33%). In 45.16%(536 deformities ) the autopsy was the sole means of establishing the cause of death or identifying genetic factors, which provides basis for further prenatal diagnosis and eugenic counsel.