| 超氧化物歧化酶对心肌线粒体再给氧损伤的作用 |
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| 引用本文： | 申田生,杨继声,王俊宏.超氧化物歧化酶对心肌线粒体再给氧损伤的作用[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 申田生 杨继声 王俊宏 |
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| 作者单位： | 西安医科大学克山病研究室
(申田生)，西安医科大学病理生理学教研室
(杨继声)，西安医科大学病理生理学教研室(王俊宏) |
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| 摘 要： | 本文目的是观察大鼠离体心脏缺氧后再给氧心肌线粒体呼吸功能的改变及超氧化物歧化酶(SOD)的作用。结果表明,心肌缺氧40min后再给氧20min,线粒体呼吸功能(呼吸控制率RCR,P/O比值)及线粒体琥珀酸脱氢酶(SDH)、细胞色素氧化酶(CCO)活性显著降低;应用SOD,可明显提高RCR、P/O值,保护SDH、CCO活性。
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| 关 键 词： | 心肌线粒体 再灌流损伤 线粒体呼吸 线粒体呼吸酶 超氧化物歧化酶 |
THE EFFECTS OF SUPEROXIDE DISMUTASE ON MYOCARDIAL MITOCHONDRIA INJURED BY REOXYGENATED PERFUSION |
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| Shen Tiansheng,Yang Jisheng,Wang Junhong.THE EFFECTS OF SUPEROXIDE DISMUTASE ON MYOCARDIAL MITOCHONDRIA INJURED BY REOXYGENATED PERFUSION[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Shen Tiansheng Yang Jisheng Wang Junhong |
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| Institution: | Department of Pathophysiology |
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| Abstract: | The effects of superoxide dismutase (SOD) on mitochondrial function after hypoxic and reoxygenated perfusions in isolated rat hearts were observed. Significant decreases in respiration control ratio (RCR) and ADP/O ratio (P/O) as well as activities of succinic dehydrogenase (SDH) and cytochrome oxidase (CCO) were found alter 40 minutes' hypoxia and 20 minutes' reoxygenated perfusion. Adding SOD to the perfusion fluid during the reperfusion period could restore the decreased mitochondfial function, which was shown by increased RCR and P/O as well as activities of SDH and CCO. |
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| Keywords: | myocardial mitochondria reperfusion injury mitochondrial spiration succinic dehydrogenase |
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