| 西安地区汉人GPT遗传多态性研究 |
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| 引用本文： | 王惠玲,赵钧海,葛淑敏.西安地区汉人GPT遗传多态性研究[J].西安交通大学学报(医学版),1996(3). |
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| 作者姓名： | 王惠玲 赵钧海 葛淑敏 |
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| 作者单位： | 西安成人教育学院 |
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| 摘 要： | 用琼脂糖－淀粉混合凝胶电泳法结合特异组织酶染色技术，对汉族人群红细胞谷氨酸转氨酶（ＧＰＴ）的遗传多态性进行研究。结果表明：该方法灵敏快速，分辨率高。ＧＰＴ可分为ＧＰＴ１－１型；ＧＰＴ２－２型；ＧＰＴ２－１型。基因频率ＧＰＴ１为０．５３６８，ＧＰＴ２为０．４６３２，符合Ｈａｒｄｙ－Ｗｅｒｉｎｂｅｒｇ平衡定律。ＧＰＴ分型在人群个体间的识别ＤＰ值为０．６２４９，是法医个人识别和亲权鉴定非常有用的遗传标记，也可作为异体骨髓移植成功在接的诊断指标。
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| 关 键 词： | 电泳 谷丙转氨酶 遗传多态性 基因频率 |
A STUDY ON THE GENETIC POLYMORPHISM OF GPT IN HANS OF XI'AN |
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| Wang Huiling,Zhao Junhai,Ge Shumin.A STUDY ON THE GENETIC POLYMORPHISM OF GPT IN HANS OF XI'AN[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1996(3). |
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| Authors: | Wang Huiling Zhao Junhai Ge Shumin |
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| Institution: | Adult Educational College |
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| Abstract: | The genetic Ploymorphism of Glutamic pyruric-transaminase (GPT) in the Hans red cells was carried out by using agar-starch mixed gel electrophoresis and tissue special staining. The method was proved to be sensitive, hish-speed and with high resolution .The GPT fell into three categories: GPT1-1, GPT2-2 and GPT2-1 phenotypes, in which the gene frequencies of GPT1 and GPT2 were 0.5368, 0.4632 respectively, according with Hardy-Weinberg Epuilibrium Law. The individual identiflcability of GPT in Hans DP was 0.6249.This is a very useful genetic marker for the forensic medicine paternity test and individual identification,and also for bone marrow transplantation as a diagnosismarker. |
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| Keywords: | electrophoresis glutamic pyruric-transaminase genetic polymorphism gene frequencies |
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