| 硒对培养心肌细胞缺血缺氧的保护作用 |
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| 引用本文： | 郑建杰,李兆志,黄庆恒,耿希刚,赵健.硒对培养心肌细胞缺血缺氧的保护作用[J].西安交通大学学报(医学版),1999(1). |
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| 作者姓名： | 郑建杰 李兆志 黄庆恒 耿希刚 赵健 |
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| 作者单位： | 第一附属医院心血管外科!西安７１００６１ |
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| 摘 要： | 向培养的乳鼠心肌细胞，在缺血缺氧时加入不同剂量的亚硒酸钠（Ｎａ２ＳｅＯ３），发现适量硒使缺血缺氧时的心肌细胞乳酸脱氢酶（ＬＤＨ）释放减少，谷胱甘肽过氧化物酶（ＧＰＸ）活性增加，同时能降低雨二醛（ＭＤＡ）含量。且增强心肌细胞膜的流动性；而超量硒能加剧心肌细胞缺血时的损害。提示：适量硒对培养心肌细胞缺血缺氧的损伤具有保护作用；超量硒函则加重其损伤。
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| 关 键 词： | 硒 乳鼠 心肌细胞 缺血缺氧 |
THE PROTECTIVE EFFECTS OF SELENIUM ON CULTURALING MYOCARDIAL CELLS ISCHEMIA AND HYPOXIA |
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| Zheng Jianjie, Li Zhaozhi, Huang Qingheng et al.THE PROTECTIVE EFFECTS OF SELENIUM ON CULTURALING MYOCARDIAL CELLS ISCHEMIA AND HYPOXIA[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(1). |
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| Authors: | Zheng Jianjie Li Zhaozhi Huang Qingheng |
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| Abstract: | We added sodium selenite to ischemia and hypoxia culturaling myocardial cell medium. The results showed that proper dose of selenium could reduce the quantity of lactate dehydrogenase (LDH) released by ischemia and hypoxia cells,the activity of Glutathione peroxidase (GPX) increasde. At the same time, the content of malondialdehyde (MDA) in myocardial cells could be reduced, and the fluidity of myocardial cells' membrane also be increased. Whereas excess seleniumcould increase the damage to myocardial cells duringischemia. So we think that proper dose of seleniumhas protective effect on culturaling myocardial cellswhen they are ischemia and hypoxia and excess selenium has opposite effect. |
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| Keywords: | selenium infant rat myocardial cell ischemial hypoxia |
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