| 醒脑胶囊对多发脑梗塞致学习记忆障碍的影响及其机理研究 |
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| 引用本文： | 王敬卿,李锐,陈松盛,郑清莲.醒脑胶囊对多发脑梗塞致学习记忆障碍的影响及其机理研究[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 王敬卿 李锐 陈松盛 郑清莲 |
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| 作者单位： | Dept.of TCM，First Affiliated Hospital |
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| 基金项目： | 陕西省中医药管理局科研基金 |
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| 摘 要： | 经水迷宫、电磁流量计、同位素标记微球法及碱羟胺比色法对学习记忆障碍大鼠模型的学习记忆能力、脑血流量（Ｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ，ＣＢＦ）、海马和皮质的局部脑血流量（Ｒｅｇｉｏｎａｌｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ，ｒＣＢＦ）及乙酰胆碱（Ａｃｈ）含量进行测定。结果显示：醒脑胶囊（ＸＮ）组ＣＢＦ较脑复康、模型组均高，ＸＮ组、脑复康组大鼠皮质和海马的ｒＣＢＦ和Ａｃｈ含量均较模型组增加，且ＸＮ组海马ｒＣＢＦ和Ａｃｈ含量较脑复康组高；ＸＮ组学习记忆能力亦优于其它两组。提示，ＸＮ可改善多发脑梗塞大鼠的学习记忆缺损，其机理可能与ＣＢＦ或ｒＣＢＦ增加尤其是海马ｒＣＢＦ升高、Ａｃｈ含量增加密切有关。
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| 关 键 词： | 多发脑梗塞 学习记忆障碍 醒脑胶囊 局部脑血流量 脑血流量 乙酰胆碱 |
EFFECT AND MECHANISM OF XINGNAO CAPUSLE ONLEARNING AND MEMORY DEFICITS IN A MULTIINFARCT RAT MODEL |
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| Wang Jingqing,Li Rui,Chen Songsheng et al.EFFECT AND MECHANISM OF XINGNAO CAPUSLE ONLEARNING AND MEMORY DEFICITS IN A MULTIINFARCT RAT MODEL[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Wang Jingqing Li Rui Chen Songsheng |
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| Abstract: | We obeserved the effects of Xingnao Capusle(XC),a selected TCM compound, on learning and memory abilities ,cerebral blood flow (CBF),regional cerebral blood flow(rCBF) and Ach concentration in hippocampus and cortex in a cognitive deficit rat model caused by cerebral multiinfarction.The results showed that CBF,rCBF and Ach in hippocampus and cortex, and learning and memory deficits were greatly improved by XC administration.The effecacy was more obvious than that of Piracetam.It suggests that XC can improve learning and memory deficits of vascular dementia.Its mechanism is partially due to the increases of rCBF and Ach concentration in hippocampus. |
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| Keywords: | multiinfarct dementia Xingnao Capusle regional cerebral blood flow Ach |
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