| 多抗乙素对小鼠S_(180)肉瘤中免疫活性细胞浸润的影响 |
| |
| 引用本文： | 徐长福,司履生,方亮.多抗乙素对小鼠S_(180)肉瘤中免疫活性细胞浸润的影响[J].西安交通大学学报(医学版),1992(3). |
| |
| 作者姓名： | 徐长福 司履生 方亮 |
| |
| 作者单位： | 西安医科大学病理解剖学教研室，西安医科大学病理解剖学教研室，西安医科大学病理解剖学教研室 西安 710061，西安 710061，西安 710061 |
| |
| 摘 要： | 曾经证明多抗乙素有明显的抑瘤作用。本文以小鼠实验性S_(180)肉瘤为模型观察了多抗乙素对肿瘤组织内和肿瘤周围Mφ、L_3T_4~- 及Lyt_2~-细胞的影响,同时观察了肿瘤坏死组织周围中性粒细胞浸润及小血管内血栓形成的改变。结果提示:Pb治疗组,肿瘤周围及肿瘤内浸润的L_3T_4~-和Lyt_2~-细胞显著增多,说明Pb可诱导肿瘤组织中淋巴细胞浸润;肿瘤组织的坏死灶周围明显充血、小血管血栓形成显著增加,并有带状中性粒细胞浸润。这些改变与TNF介导的肿瘤组织损伤相符,提示Pb的抑瘤作用主要是通过免疫活性细胞产生的TNF实现的。
|
| 关 键 词： | S_(180)肉瘤 L_3T_4~+细胞 Lyt_2~+细胞 肿瘤坏死因子 多抗乙素 |
THE EFFECT OF POLYACTIA B ON TUMOR-INFILTRATING IMMUNOCOMPETENT CELLS WITIHN MURINE S_(180) SARCOMA |
| |
| Xu Changfu,Si Lusheng,Fang Liang.THE EFFECT OF POLYACTIA B ON TUMOR-INFILTRATING IMMUNOCOMPETENT CELLS WITIHN MURINE S_(180) SARCOMA[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(3). |
| |
| Authors: | Xu Changfu Si Lusheng Fang Liang |
| |
| Institution: | Department of Pathology |
| |
| Abstract: | Polyactin B (Pb) has been proved to have the effect of considerable tumor suppression. Recently,we used murine S_(180) Sarcoma as a model and observed the effect of Pb on the tumor—infiltrating immunocompetent cells, and also the infiltrating neutrophils and the alteration of small blood vessels within the tumor tissue. Compared with control: in Pb—treated group, there were more L_3T_4~+and Lyt_2~+ lymphocytes infiltrating in the periphery of the tumor ,and also within the tumor. In addition, the tumors had more prominant hyperemia, micro—thrombosis and neutrophil infiltration around the necrotic areas. The present findings suggest that the tumor—suppression effect of Pb might be mediated through TNF produced by immunocompetent cells. |
| |
| Keywords: | S_(180) sarcoma L_3T_4~+ cell Lyt_2~+ cell tumor necrosis factor (TNF) polyaction B (Pb) |
| 本文献已被 CNKI 等数据库收录！ |
