| CD147蛋白在人宫颈癌中的表达 |
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| 引用本文： | 周希,冀静,吴怡,郑鹏生.CD147蛋白在人宫颈癌中的表达[J].西安交通大学学报(医学版),2010,31(1). |
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| 作者姓名： | 周希 冀静 吴怡 郑鹏生 |
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| 作者单位： | 1. 西安交通大学医学院第一附属医院妇产科学系生殖医学科,环境与疾病相关基因教育部重点实验室,陕西西安,710061;郧阳医学院附属人民医院妇产科,湖北十堰,442000
2. 西安交通大学医学院第一附属医院妇产科学系生殖医学科,环境与疾病相关基因教育部重点实验室,陕西西安,710061 |
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| 基金项目： | 国家自然科学基金，国家自然科学杰出青年基金，教育部985-2期工程 |
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| 摘 要： | 目的 探讨CD147在宫颈癌中的表达及其意义.方法 应用蛋白印迹及免疫组织化学方法检测CD147在宫颈癌和正常宫颈组织中的表达.结果 CD147蛋白在所有的宫颈癌(41/41,100.0%)和绝大多数正常宫颈组织(11/12,91.7%) 都表达.宫颈组织中存在着不同分子量的CD147分子.CD147在宫颈癌中的细胞阳性率及表达量都要显著高于正常组织(P<0.05).结论 CD147是细胞增殖的一个标记分子;CD147 蛋白在宫颈癌中高表达,是宫颈癌治疗的一个潜在靶点.
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| 关 键 词： | 宫颈癌 蛋白印迹 免疫组化 |
Expression of CD147 protein in human cervical carcinoma |
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| ZHOU Xi,JI Jing,WU Yi,ZHENG Peng-sheng.Expression of CD147 protein in human cervical carcinoma[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(1). |
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| Authors: | ZHOU Xi JI Jing WU Yi ZHENG Peng-sheng |
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| Institution: | ZHOU Xi1,2,JI Jing1,WU Yi1,ZHENG Peng-sheng1(1.Department of Reproductive Medicine in Gynecology , Obstetrics,the First Affiliated Hospital,Key Laboratory of Environment , Genes Related toDiseases of Ministry of Education,Medical School of Xi\'an Jiaotong University,Xi\'an 710061,2.Department of Obstetrics , Gynecology,Affiliated Renmin Hospital,Yunyang Medical College,Shiyan 442000,China) |
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| Abstract: | Objective To investigate the expression of CD147 and its significance in human cervical carcinoma.Methods Western blotting and immunohistochemical staining were used to detect CD147 expression in cervical cancer or normal cervix uteri tissues.Results CD147 protein was expressed in all of cervical carcinomas(41/41,100.0%) and most of normal cervix uteri tissues(11/12,91.7%).CD147 with different molecular weights were present in cervical tissues.The percentage of CD147-positive cells and the expressional leve... |
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| Keywords: | CD147 CD147 cervical carcinoma Western blotting immunohistochemical staining |
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