| 基质金属蛋白酶-2及其抑制因子TIMP-2 在脑胶质瘤中的表达及意义 |
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| 引用本文： | 周任,柏鲁宁,王睿智,张龙洲,包新杰,曹杰.基质金属蛋白酶-2及其抑制因子TIMP-2 在脑胶质瘤中的表达及意义[J].西安交通大学学报(医学版),2008,29(6). |
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| 作者姓名： | 周任 柏鲁宁 王睿智 张龙洲 包新杰 曹杰 |
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| 作者单位： | 1. 西安交通大学医学院第二附属医院神经外科,陕西西安,710004
2. 陕西中医学院附属医院神经外一科,陕西咸阳,712000 |
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| 摘 要： | 目的探讨基质金属蛋白酶-2(MMP-2)及其抑制因子TIMP-2的表达及其与脑胶质瘤恶性程度之间的关系。方法采用免疫组化SP法检测并比较了67例不同级别胶质瘤组织和10例正常脑组织中MMP-2和TIMP-2蛋白的表达情况。结果随着肿瘤恶性程度的增加,MMP-2蛋白表达增高而TIMP-2蛋白表达降低。结论MMP-2及TIMP-2对胶质瘤恶性程度的评估有重要的意义。
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| 关 键 词： | 基质金属蛋白酶 基质金属蛋白酶抑制因子 神经胶质瘤 |
Expression of MMP-2 and its inhibitor TIMP-2 in human glioma |
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| Zhou Ren,Bai Luning,Wang Ruizhi,Zhang Longzhou,Bao Xinjie,Cao Jie.Expression of MMP-2 and its inhibitor TIMP-2 in human glioma[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2008,29(6). |
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| Authors: | Zhou Ren Bai Luning Wang Ruizhi Zhang Longzhou Bao Xinjie Cao Jie |
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| Institution: | Zhou Ren1,Bai Luning2,Wang Ruizhi1,Zhang Longzhou1,Bao Xinjie1,Cao Jie1 |
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| Abstract: | Objective To explore the expression of matrix metalloproteinase-2 (MMP-2) and its inhibitor tissue inhibitor of metalloproteinase-2 (TIMP-2) and their relation with glioma of different malignancy degree. Methods Immunohistochemical SP method was employed to examine the level of MMP-2 and TIMP-2 in surgical samples from 67 patients suffering from gliomas and 10 patients with cerebral trauma. Results As the tumor's malignancy degree increased, the expression of MMP-2 increased but the expression of TIMP-2 decreased as the tumor malignancy degree increased. Conclusion MMP-2 and TIMP-2 have a great significance in evaluating the malignancy degree of human gliomas. |
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| Keywords: | matrix metalloproteinases-2 (MMP-2) tissue inhibitor of metalloproteinase-2 (TIMP-2) glioma |
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