棉酚宫腔给药对大鼠的抗生育作用

用妊娠2、4和6天的大鼠,按妊娠期各分为实验组与对照组。实验组向一侧子宫角内注射0.1ml醋酸棉酚注射液(含棉酚0.5mg或1mg),对照组向一侧子宫角内注射0.1ml生理盐水。于妊娠12～13天处死动物,观察两组动物双侧子宫角内胚胎存活情况。结果表明实验组动物无论妊娠2、4、6天,注射1mg棉酚侧子宫角内的胚胎死亡率皆明显高于未注射侧;而对照组动物注射盐水侧子宫角内胚胎死亡率与未注射侧比较无显著差异。实验提示棉酚直接宫腔内一次给药可能是用于终止早期妊娠的一种有效药物。

EFFECT OF INTRAUTERINE INJECTION OF GOSSYPOL ON ANTIFERTILITY ACTION IN RATS

Rats of 2,4 and 6 days of pregnancy were divided into the test and the contro(?) group respectively. 0.1 ml of gossypol acetate injection(containing o.5mg or 1mg of gossypol) was injected into one of the two uterine horns of the rats in the test group and their contralateral horns served as control. The control grou(?) received 0.1 ml of normal saline in one of the two uterine horns and the contralateral horns served as control. On 12～13 days of pregnancy all the rats in each group were sacrificed. It was found that in the test group the number of died embryo in the horns after the injection of gossypol(1 mg) was much greater than that in the contralateral horns(P<0.001).In the control group the number of died embryo in the horns after the injection of normal saline showed no significant difference in comparison with the contralateral horns. This suggests that a single injection of a small dosage of gossypol into the uterus may be used to stop early pregnancy.