| 原发性高血压患者氨苯喋啶敏感性钠通道β亚单位基因12外显子的PCR-SSCP分析 |
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| 引用本文： | 薛明战,刘治全,侯嵘,刘文辉,刘杰.原发性高血压患者氨苯喋啶敏感性钠通道β亚单位基因12外显子的PCR-SSCP分析[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 薛明战 刘治全 侯嵘 刘文辉 刘杰 |
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| 作者单位： | Research Laboratory of Clinical Genetics，First Clinical Medical College |
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| 摘 要： | 为确定原发性高血压患者是否存在氨苯喋啶敏感性钠通道（Ａｍｉｌｏｒｉｄｅｓｅｎｓｉｔｉｖｅｓｏｄｉｕｍｃｈａｎｎｅｌ，ＡＳＳＣ）β亚单位基因第１２外显子ＤＮＡ片段突变，本研究采用ＰＣＲ－ＳＳＣＰ技术对１４８例确诊型高血压病患者的ＡＳＳＣβ亚单位基因第１２外显子进行了分析。结果在原发性高血压患者中检出了３例有ＡＳＳＣβ亚单位基因第１２外显子突变的个体。提示原发性高血压的发生与ＡＳＳＣβ亚单位基因第１２外显子突变有关，它可能是原发性高血压发生的分子基础之一。
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| 关 键 词： | 原发性高血压 遗传学 氨苯喋啶敏感性钠通道 |
THE STUDY OF AMILORIDE SENSITIVE SODIUM CHANNEL SUBUNIT EXON 12 GENE MUTATION BY PCRSSCR IN PRIMARY HYPERTENSION |
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| Xue Minzhan,Liu Zhiquan,Hou Rong et al.THE STUDY OF AMILORIDE SENSITIVE SODIUM CHANNEL SUBUNIT EXON 12 GENE MUTATION BY PCRSSCR IN PRIMARY HYPERTENSION[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Xue Minzhan Liu Zhiquan Hou Rong |
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| Abstract: | To investigate exon 12 of amiloride sensitive sodium channel (ASSC) subunit gene mutation in patients with primary hypertension ,in 148 definite primary hypertension subjects, PCRSSCP was used to screen and define the mutation .The results showed that there were SSCP change of ASSC subunit gene exon 12 in 3 cases.It is suggested that mutation of ASSC subunit gene exon 12 may be related to primary hypertension,and this gene mutation may be one of the molecular mechanisms for some common forms of patients with primary hypertension. |
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| Keywords: | primary hypertension genetics amiloride sensitive sodium channel |
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