| 人微小病毒B19及硒与大骨节病关系的研究 |
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| 引用本文： | 熊咏民,王治伦,代晓霞,陈群,杨占田,谭希望,耿冬.人微小病毒B19及硒与大骨节病关系的研究[J].西安交通大学学报(医学版),2004,25(1):45-47. |
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| 作者姓名： | 熊咏民 王治伦 代晓霞 陈群 杨占田 谭希望 耿冬 |
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| 作者单位： | 西安交通大学医学院地方病研究所,陕西西安,710061 |
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| 基金项目： | 国家自然科学基金资助项目 (No .39770 6 6 7) |
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| 摘 要： | 目的 研究人微小病毒B19(B19)感染和硒与大骨节病的关系。方法 采用聚合酶链反应 (PCR)及荧光法检测大骨节病病区儿童血清B19DNA和红细胞硒含量 ,并与非病区健康儿童进行对比分析。结果 大骨节病病区儿童血清B19感染率显著高于非病区儿童 ,红细胞硒含量显著低于非病区儿童 ,低硒营养状态的儿童B19感染率明显高于正常硒水平的儿童。结论 我国大骨节病病区存在着B19感染的流行 ,低硒可能是B19感染发生和发展的条件。
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| 关 键 词： | 大骨节病 人微小病毒B19 聚合酶链反应 硒 |
| 文章编号： | 1671-8259(2004)01-0045-03 |
| 修稿时间： | 2003年7月10日 |
Relationship of human parvovirus B19 with selenium and Kashin-Beck disease |
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| Xiong Yongmin,Wang Zhilun,Dai Xiaoxia,Chen Qun,Yang Z hantian,Tan Xiwang,Geng Dong.Relationship of human parvovirus B19 with selenium and Kashin-Beck disease[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2004,25(1):45-47. |
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| Authors: | Xiong Yongmin Wang Zhilun Dai Xiaoxia Chen Qun Yang Z hantian Tan Xiwang Geng Dong |
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| Abstract: | Objective To study the association of human parvo virus B19 (B19) infection with Kashin-Beck disease(KBD)and selenium (Se). Methods B19 DNA was amplified for serum of children in KBD endemic area and children in KBD non-endemic area by polymerase chain reaction (PCR) technique, and the content of erythrocyte selenium was determined by DAN f luorescence spectrophotometry. Results The frequency of B19 infection in KBD endemic area was higher than that of healthy children in KBD non-endemic area. The content o f erythrocyte selenium in KBD endemic area was much lower than that KBD non-end emic area, and the B19 infection rate in low-Se children was higher than that i n normal children. Conclusion The children in KBD endemic area have high B19 i nfection, and Se deficiency plays a significant role in the development of B19 i nfection. |
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| Keywords: | Kashin-Beck disease human parvovirus B19 polym erase chain reaction selenium |
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