| 多发脑梗死血浆内皮素的动态变化及补肾化瘀中药的影响 |
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| 引用本文： | 李锐,王敬卿,陈松盛,郑清莲,王晋源.多发脑梗死血浆内皮素的动态变化及补肾化瘀中药的影响[J].西安交通大学学报(医学版),1999,20(3):353-355. |
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| 作者姓名： | 李锐 王敬卿 陈松盛 郑清莲 王晋源 |
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| 作者单位： | 西安医科大学第一临床医学院中西医结合研究所,西安,710061 |
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| 基金项目： | 陕西省中医药管理局资助课题 |
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| 摘 要： | 采用放射免疫分析（ＲＩＡ）对多发脑梗死模型组大鼠和补肾益脑、活血化瘀中药治疗组血浆内皮素（Ｅｎｄｏｔｈｅｌｉｎ， ＥＴ）进行动态测定，并用水迷宫试验评价其分辨性学习记忆能力。结果表明：多发脑梗死血浆ＥＴ存在先迅速升高，７ｄ 达峰后迅速下降，至１４ｄ 达正常水平的时相变化；补肾益脑、活血化瘀中药组各时期ＥＴ水平均显著低于模型组（ Ｐ＜ ０．０５），且前者学习记忆能力缺损轻于后者（ Ｐ＜ ０．０５）。提示补肾益脑、活血化瘀中药通过降低局部ＥＴ而改善脑梗死的结局
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| 关 键 词： | 脑梗死 记忆 大鼠 内皮素 中药 |
DYNAMIC CHANGES OF PLASMA ENDOTHELIN IN A CEREBRAL MULTI-INFARCT RAT MODEL AND EFFECTS OF CHINESE HERBS |
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| Li
Rui, Wnag Jingqing ,Cheng Songsheng et al.DYNAMIC CHANGES OF PLASMA ENDOTHELIN IN A CEREBRAL MULTI-INFARCT RAT MODEL AND EFFECTS OF CHINESE HERBS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999,20(3):353-355. |
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| Authors: | Li
Rui Wnag Jingqing Cheng Songsheng |
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| Abstract: | We observed time course changes of plasma endothelin(ET) and the effects of TCM compound in a cerebral multi infarct rat model,meanwhile learning and memory abilities of distinguishing tasks were also assessed. Results showed that plasma ET concentration increased rapidly untill 7day after cerebral infarction.After fourteen days plasms ET was close to basic level.Administration of the TCM compound, which was developed according to principals of invigorating the kidney and removing blood stasis, could decrease ET level of 3、7、10、14 days after infarction and improve deficits of learning and memory in distinguishing tasks.It indicates that the compound can improve the outcome of cerebral multi infarction.Its mechanism is partially due to the decrease of plasma ET. |
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| Keywords: | cerebral infarct learning memory rat endothelin Chinese herbs |
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