胃癌癌旁及非癌胃粘膜内分泌细胞的研究

用胃泌素及生长抑素兔抗人抗体，ABC疫组化法，对55例手术之胃癌癌旁粘膜及67例非癌胃粘膜中的G细胞及D细胞进行了定位计数，观察其数值变化，初步探讨它们在胃癌发生发展中的作用。结果显示癌旁窦粘膜中G细胞及D细胞每平方毫米的平均数显著低于正常及CSG窦粘膜（P＜0．01及P＜0．05）。提示当窦粘膜内G细胞及D细胞的数量减少至正常值的1／3左右时，胃粘膜上皮严重失去激素的营养调节作用，容易接受内外源性致癌物的作用而发生癌变。

THE STUDY OF ENDOCRINE CELLS IN THE PARACANCEROUS AND NONCANCEROUS GASTRIC MUCOSA

The paracancerous gastric mucosafrom the operation specimens of 55 patients withgastric carcinomas and the gastric mucosa from thebiopsies of 67 patients without cancers were studiedwith ABC immunohistochemical method. G cell andD cell in these mucosas were counted and their locations were ascertained for detecting the relationshipbetween the pathogenesis of gastric carcinoma andgastric endocrine cells. The results revealed that thenumbers of the G cells and D cells in the paracancerous mucosa of gastric antra on the average persquare millimetre were prominently lower thanthose of the normal mucosa and of the chronic superficial gastritis mucosa of antra (P < 0. 01 for Gcells ; and P <0. 05 for D cells). It suggested thatthe endocrinal nutrient regulation to the gastric epithelial cells were losing step by step, especiallywhen the numbers of the G cells and D cells reducedto one third of the numbers of those cells in the normal mucosa of gastric antra. And, in this case, theepithelial cells of mucosa were susceptible to thecarcinogen.