| 桥本氏甲状腺炎与Bf遗传多态现象相关性研究 |
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| 引用本文： | 薛明战,林田,施秉银,高慧.桥本氏甲状腺炎与Bf遗传多态现象相关性研究[J].西安交通大学学报(医学版),1995(2). |
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| 作者姓名： | 薛明战 林田 施秉银 高慧 |
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| 作者单位： | 妇幼卫生系临床遗传学教研室，第一附属医院内分泌代谢病研究室，第一附属医院内分泌代谢病研究室 西安710061，医学遗传研究室 |
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| 摘 要： | 用琼脂糖凝胶高压电泳及免疫固定技术分析了83例桥本氏甲状腺炎患者的Bf遗传多态性,并将其表型及等位基因频率与326例健康对照组人群作了比较。结果发现,病人组的BfFF频率显著高于对照组（x~2=9.677,P<0.0025）;而Bf的其它表型及等位基因频率在两组间无差别。关联分析表明,桥本氏甲状腺炎与BfFF呈正相关（RR=4.778）
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| 关 键 词： | 桥本氏甲状腺炎 遗传学 Bf遗传多态性 |
STUDY OF ASSOCIATION BETWEEN HASHIMOTO' DISEASE AND Bf POLYMORPHISM |
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| Xue Mingzhan,Shi Bingyin,Lin Tian,et al.STUDY OF ASSOCIATION BETWEEN HASHIMOTO' DISEASE AND Bf POLYMORPHISM[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1995(2). |
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| Authors: | Xue Mingzhan Shi Bingyin Lin Tian |
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| Abstract: | 83 cases with Hashimoto' thyroiditis (HT) typed for Bf phenotype were analysed using high voltage agarose gel electropherosis and im-munofixation. Compared with 326 controls, the frequencies of BfFF were increased significantly in thegroup of patients (X2= 9.677, P < 0. 0025) , There was no difference between two groups in the other Bf phenotypes and allele. The association analysis showed that there was a positive association between HT and BfFF (RR = 4. 778). |
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| Keywords: | Hashimoto thyroiditis genetics Bf polymorphism |
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