| 慢性神经病理性痛对小鼠细胞免疫功能的影响 |
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| 引用本文： | 邵玲巧,Yuan Yukang,袁育康,王军阳,任会勋.慢性神经病理性痛对小鼠细胞免疫功能的影响[J].西安交通大学学报(医学版),2007,28(3):252-254. |
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| 作者姓名： | 邵玲巧 Yuan Yukang 袁育康 王军阳 任会勋 |
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| 作者单位： | 1. 西安交通大学医学院免疫学与病原生物学系,陕西西安,710061;西安医学院微生物学与免疫学教研室,陕西西安,710068
2. 西安交通大学医学院免疫学与病原生物学系,陕西西安,710061 |
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| 摘 要： | 目的探讨慢性神经病理性痛对小鼠细胞免疫功能的影响。方法在通过结扎小鼠单侧胫神经和腓总神经建立慢性坐骨神经病理性疼痛模型的基础上,利用淋巴细胞增殖试验(MTT法)和酶联免疫吸附试验(ELISA)动态观察慢性神经病理性疼痛对T淋巴细胞增殖活性以及血清中肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的影响。结果神经病理性疼痛模型小鼠的T淋巴细胞增殖活性明显高于假手术组及对照组,外周血液中的TNF-α和IL-6亦明显高于假手术组及对照组。结论小鼠在慢性神经病理性疼痛状态下细胞免疫功能明显增强。
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| 关 键 词： | 神经病理性痛 肿瘤坏死因子 白介素-6 T淋巴细胞 |
| 文章编号： | 1671-8259（2007）03-0252-03 |
| 修稿时间： | 2006-05-122006-07-10 |
The influence of chronic neuropathic pain on cellular immune function of mice |
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| Yuan Yukang.The influence of chronic neuropathic pain on cellular immune function of mice[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2007,28(3):252-254. |
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| Authors: | Yuan Yukang |
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| Abstract: | Objective To explore the influence of chronic neuropathic pain on cellular immune function of mice models.Methods The mice models were established by ligating tibeal nerve and common peroneal nerve on one side,and the influence of chronic neuropathic pain on cellular immune function and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) was observed with lymphocyte cell increase experiment(MTT method) and enzyme linked immunosorbent assay(ELISA).Results The increased reactivity of T lymphocyte of the model group was significantly higher than that of the sham group and the control group.At the same time,content of TNF-α and IL-6 in blood of the model group also increased.Conclusion Cellular immune function of mice is increased in the state of chronic neuropathic pain. |
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| Keywords: | chronic neuropathic pain tumor necrosis factor-α interleukin-6 T lymphocyte |
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