犬冠状动脉内植入肝素涂层国产支架的实验研究

目的　探讨明胶涂层支架介导肝素局部给药的可行性及疗效。方法　体外通过同位素标记的肝素测量涂层支架吸附肝素的量及峰时间 ;动物实验将家犬分两组 ,对照组植入裸支架 (n=1 2 ) ,实验组植入肝素涂层支架 (n=1 0 ) ,于 1、4周两个时间点观察血栓的发生情况。结果　明胶涂层支架吸附肝素的量随肝素浓度的增加亦增加 ,且最大吸附时间在 30 min左右 ;动物实验证明肝素涂层支架可预防冠状动脉内支架内血栓形成。结论　明胶涂层支架介导的局部肝素给药疗效好、方法简洁有效 ,值得进一步研究推广

An experimental study of deployment of heparin coated national stent into dog coronary artery

Objective The feasibility and curative effects of gelatin coated national Pt Ir alloy stent mediated local heparin delivery were studied in vivo and ex vivo.Methods In ex vivo experiment, 99m Te labeled heparin was used to detect the amount of gelatin coated stent absorbed heparin and the maximal time;In the animal experiment, dogs were divided into two groups:the group one was control ( n =12) and deployed bare stent;the group two was heparin group( n =10);We implanted different stents into coronaries of different groups of dogs,and killed the dogs in 1 or 4 weeks, and then inspected the results by using histochemical method.Results The dose of gelatin coated stent absorbed increased with the increase of heparin concentration,and the maximal dose occured in 30min.The animal experiment indicated that heparin coated stent could diminish stent derived thrombosis.Conclusion Gelatin coated stent mediated a good effects of local heparin delivery.This method is simple and practical, it is worthy of studying and extending.