无水乙醇栓塞对肾癌微血管和碱性成纤维生长因子及其受体表达的影响

用免疫组织化学 SP法对无水乙醇栓塞后肾癌手术标本 36例及同期单纯手术切除标本1 0例中微血管数目、碱性成纤维生长因子 (b FGF)和其受体 (FGF- R)的表达进行检测 ,并进行比较。结果显示术前栓塞组的微血管数目低于手术对照组 ,且差异有显著性 (P <0 .0 0 1 ) ;b FGF和FGF- R的表达具有一致性 ,术前栓塞组 b FGF和 FGF- R阳性率为 55.6% ,手术对照组 b FGF和FGF- R阳性率为 60 % ,两组相比无显著性差异 (P >0 .0 5)。提示无水乙醇栓塞能够降低肾肿瘤微血管数目 ,并减少肿瘤血行转移的可能性

The effect of absolute ethanol embolization on microvessels and expression of basic fibroblast growth factor and its receptor in renal cell carcinoma

To study the change of microvessels, bFGF and its receptor FGF R of renal cell carcinoma after embolization with absolute ethanol. 46 cases of renal cell carcinomas proved by surgery and pathology were studied, 36 of them were embolized by absolute ethanol and 10 were treated with surgical resection alone.Streptavidin biotinperoxidase complex (SP) immunohistochemical staining with rabbit anti factor Ⅷ related antigen polyclonal antibody, bFGF rabbit polyclonal and FGF R mousc monoclonal in all specimens, then study on the correlation between two groups.The results showed that microvessels counts of embolization group were significantly higher than that of the simply surgery group (P<0.001);The expression of bFGF and FGF R was consistent ,postive rate was 55.6% in embolization group, 60% in surgery group.There was no significant difference between the two groups (P>0.05).It is suggested that embolization with absolute ethanol can decrease the microvessels counts of renal cell carcinoma,and may decrease the probability of metastasis through blood.