| 化学性交感神经切断术在大鼠糖尿病痛过敏中的作用 |
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| 引用本文： | 刘健,王克模,曹东元,何丽珍.化学性交感神经切断术在大鼠糖尿病痛过敏中的作用[J].西安交通大学学报(医学版),1996(3). |
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| 作者姓名： | 刘健 王克模 曹东元 何丽珍 |
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| 作者单位： | 西安脑和神经研究室 |
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| 摘 要： | 观察了交感传出在大鼠糖尿病痛过敏中的作用。先给大鼠腹腔注射６－羟多巴胺（６－ＯＨＤＡ）损毁交感节后神经元（ＳＰＧＮｓ）末梢后，再给予链脲佐菌素（ＳＴＺ）建立６－ＯＨＤＡ糖尿病大鼠模型。在连续６周的观察中，发现这组大鼠在行为上没有反常表现，它们的伤害性爪回缩阈值（ＮＰＷＴ）和甩尾反射潜伏期（ＴＦＵ）也没有显著变化，而糖尿病组大鼠在腹腔注射ＳＴＺ后，在行为上出现反常表现，实验至第１周时，ＴＦＬ显著缩短，第２周时，ＮＰＷＴ明显降低。结果提示ＳＰＧＮｓ在大鼠糖尿病痛过敏中起重要的作用。
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| 关 键 词： | 交感传出 糖尿病 痛过敏 |
EFFECTS OF CHEMICAL SYMPATHECTOMY ON THE DIABETIC HYPERALGESIA OF RATS |
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| Liu Jian,Wang Kemo,Cao Dongyuan,et al.EFFECTS OF CHEMICAL SYMPATHECTOMY ON THE DIABETIC HYPERALGESIA OF RATS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1996(3). |
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| Authors: | Liu Jian Wang Kemo Cao Dongyuan |
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| Institution: | Department of Brain and Nerve |
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| Abstract: | Effects of chemical sympathectomy On the diabetic hyperalgesia of rats were observed.First intral eritoneally injecting 6-hydroxydopamine (6-OHDA) to eliminate effects of sympathetic postganglionic neurons(SPGNs), then injecting streptozotocin(STZ),the model of diabetic rats with 6-OHDA was set up. This group of rats had no abnormal expression in behaviour and their nociceptive paw-with-drawal threshold (NPWT) and tail flick latency(TFL)did not change significantly for continuous six weeks.However,after the group of diabetic were intraperitoneally injected with STZ, their behavioral expressionwas abnormal, at the time of first week after the experiment, TFL was significantly reduced, at the time of second week, NPWT was decreased obviously.The results suggest that SPGNs play an important role in the diabetic hyperalgesia of rats. |
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| Keywords: | sympathetic efferent diabetes hyperalgesia |
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