| 初级传入神经释放P物质与α_2肾上腺素能受体的关系 |
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| 引用本文： | 赵晏,史文春.初级传入神经释放P物质与α_2肾上腺素能受体的关系[J].西安交通大学学报(医学版),1991(2). |
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| 作者姓名： | 赵晏 史文春 |
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| 作者单位： | 西安医科大学神经生理学研究室
(赵晏)，西安医科大学神经生理学研究室(史文春) |
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| 摘 要： | 本研究用大鼠背侧脊髓温育切片,观察了α_2肾上腺素能受体的活性对辣椒素(CAP)诱发P物质(SP)释放的影响。当灌流液中加入CAP(3μmol/L)后,SP释放增加4倍。CAP诱发的SP总释放率为0.45±0.1%,当应用α_2肾上腺素能受体激动剂可乐宁(10μmol/L)时,SP总释放率下降到0.25±0.02%(n=11,P<0.05)。育亨宾(100μmol/L)可拮抗可乐宁的效应。该结果提示,初级传入神经细纤维的中枢端的SP释放,受α_2肾上腺素能受体活性的调制。
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| 关 键 词： | P物质 α 肾上腺素能受体 痛调制 可乐宁 |
THE RELATION BETWEEN α_2-ADRENORECEPTOR AND THE RELEASE OF SUBSTANCE P FROM THE PRIMARY AFFERENT NEURONS |
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| Zhao Yan,Shi Wenchun Depatment of Neurophysiology.THE RELATION BETWEEN α_2-ADRENORECEPTOR AND THE RELEASE OF SUBSTANCE P FROM THE PRIMARY AFFERENT NEURONS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1991(2). |
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| Authors: | Zhao Yan Shi Wenchun Depatment of Neurophysiology |
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| Institution: | Zhao Yan;Shi Wenchun Depatment of Neurophysiology |
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| Abstract: | In the present study it was observed that thecapsaicin induccd the release of substance P (SP) fromthe slices of rat dorsal spinlal cord incubated in vitrowhich was inhibited by the activity ofx_2--adrenoreceptor. The relcase of SP was inercased 4 fold after the addi-tion of capsaicin (3 μmol/L) to the superfusion me-dium Total capsaicin cvoked SP relcase was 0.45±0.1%.It was reduced to 0. 25±0. 02%(n= 11, P<0. 05)whenthe x_2 --adrenoreceptor agonist clonidine (10μmol/L)was present Yohimbine (100μmol/L) antagomzed theclonidine effect. The results suggest that the releaseof SP from the central endings of primary small diame-ter afferent nerve was modulated by the activity ofx_2--adrenoreceptors. |
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| Keywords: | subatance P α_2-adrecorcccptor pain medulation clonidine |
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