| 大鼠外科型急性肝功能衰竭与多脏器功能衰竭 |
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| 引用本文： | 吕毅,潘承恩,刘学民,孟令忠,徐军,秦兆寅.大鼠外科型急性肝功能衰竭与多脏器功能衰竭[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 吕毅 潘承恩 刘学民 孟令忠 徐军 秦兆寅 |
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| 作者单位： | Department of Hepatobilliary Surgery，First Affiliated Hospital |
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| 摘 要： | 将２３只大鼠随机分为对照组和急性肝衰（ＦｕｌｍｉｎａｎｔＨｅｐａｔｉｃＦａｉｌｕｒｅ，ＦＨＦ）组，手术制成外科型ＦＨＦ模型，用血液生化检测、同位素扫描、组织形态观察，证明制作肝衰模型造成肝脏形态和功能损害外，还导致大鼠肺、肾、脑、心、肠的结构和功能均发生明显损害，并发生多脏器功能衰竭（ＭＯＦ）。其发生原因可能与肝脏网状内皮系统屏障功能削弱，内毒素血症介导的重要脏器贯序损伤有关
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| 关 键 词： | 大鼠 急性肝功能衰竭 多脏器功能衰竭 网状内皮系统 内毒素血症 |
SURGICAL FULMINANT HEPATIC FAILURE AND MULTIPLE ORGANIC FAILURE IN RAT |
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| L Yi,Pan Chengen,Liu Xuemin et al.SURGICAL FULMINANT HEPATIC FAILURE AND MULTIPLE ORGANIC FAILURE IN RAT[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | L Yi Pan Chengen Liu Xuemin |
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| Abstract: | rats were randomized into surgical fuminant hepatic failure (FHF) group and control group.With blood biochemical ,scintigraphical and histopathological research , was proved that FHF not only caused pathological and functional injury of liver ,but also apparent structural and functional injury of lung, kidney, brain,heart ,alimenatary tract, even MOF.The important reason maybe relates to impaired hepatic reticulate endothellal system ,and sequential injury of important organ induced by endotoxemia. |
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| Keywords: | rat fulminant hepatic failure (FHF) multiple organic failur(MOF) reticulate endothelial system(RES) endotoxemia |
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