| COPD患者红细胞膜流动性、氧自由基变化及抗氧化剂对其影响 |
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| 引用本文： | 王水利,苏保风,强蕴蕴,孙钢,赵岚,杨淑梅,孙升寿.COPD患者红细胞膜流动性、氧自由基变化及抗氧化剂对其影响[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 王水利 苏保风 强蕴蕴 孙钢 赵岚 杨淑梅 孙升寿 |
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| 作者单位： | 陕西临床医学院呼吸科，陕西省临床医学院检验科 |
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| 摘 要： | 检测５０例慢性阻塞性肺疾病（ＣＯＰＤ）患者红细胞膜流动性、氧自由基变化及抗氧化剂对其影响。结果：患者ＳＯＤ活性减弱，红细胞内ＭＤＡ含量增加，膜流动性下降，并且与感染及缺氧程度有关。维生素Ｃ及辅酶Ｑ１０可提高ＳＯＤ活性，阻断减弱脂质过氧化反应，增大膜流动性。
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| 关 键 词： | COPD 膜流动性 氧自由基 抗氧化剂 |
CHANGES OF ERYTHROCYTE MEMBRANE FLUIDITY AND OXYGEN FREE RADICALS AND ACTIONS OF ANTIOXIDANTS ON IT IN COPD |
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| Wang Shuili,Su Baofeng,Qiang Yunyun et al.CHANGES OF ERYTHROCYTE MEMBRANE FLUIDITY AND OXYGEN FREE RADICALS AND ACTIONS OF ANTIOXIDANTS ON IT IN COPD[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Wang Shuili Su Baofeng Qiang Yunyun |
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| Abstract: | We studied changes of erythrocyte membrane fluidity and oxygen free radicals and actions of antioxidants on it in 50 cases with COPD .The results showed that SOD were obviously decreased;Internal erythrocyte MDA content and membrane microviscosity were significantly increased;Membrane fluidity were decreased as compared with the control group.These were related to degree of infection and anoxia.Vitamin C and coenzyme Q10 were capable of improving SOD activities, disturbing lipid peroxidation and enlarging membrane fluidity.These results suggest that antioxidants might play an important role in the process of COPD treatment. |
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| Keywords: | COPD membrane fluidity oxygen free radicals antioxidants |
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