| 小剂量阿霉素对大鼠左心室功能的影响 |
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| 引用本文： | 王俊宏,卢兴,杨继声.小剂量阿霉素对大鼠左心室功能的影响[J].西安交通大学学报(医学版),1988(3). |
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| 作者姓名： | 王俊宏 卢兴 杨继声 |
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| 作者单位： | 西安医科大学病理生理学教研室
(王俊宏，卢兴)，西安医科大学病理生理学教研室(杨继声) |
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| 摘 要： | 本文以小剂量(1mg/kg/次)阿霉素腹腔注射,每周一次共计10周。第11周测定左心室功能,结果显示:1.血压、心输出量、每搏量及心率无明显改变;2.左心室内压力峰值无明显改变,+dp/dtmax明显降低(对照组为728.88±38.39 KPa/s,ADM组为626.77±25.59,p<0.05),降低幅度为14%;3.-dp/dtmax明显降低(对照组为618.78±39.86 Kpa/s,ADM组为461.75±20.53,p<0.05),降低了25%,T值由对照的17±1ms延长至24±2ms,增加了41%(p<0.05);4.△P/△V无显著性改变。结果说明在严重的心力衰竭发生之前,反映心脏舒张性能的指标(T值、-dp/dtmax)已有明显改变,较为敏感。
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| 关 键 词： | 阿霉素 大鼠 心功能 |
THE EFFECT OF ADRIAMYCIN ON LEFT VENTRICULAR FUNCTION IN RATS |
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| Wang Junhong,et al.THE EFFECT OF ADRIAMYCIN ON LEFT VENTRICULAR FUNCTION IN RATS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1988(3). |
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| Authors: | Wang Junhong |
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| Institution: | Department of Pathophysiology |
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| Abstract: | In order to study the changes of cardiac function in adriamycin-induced cardiomyopathyadriamycin had been given to the rats in a small dosage(1mg/kg body weight, every week) for ten weeks. Cardiac functions were measured after the pretreatment. The results indicated that: 1. arterial blood pressure, cardiac output, stroke volume and heart rate had not changed significantly; 2. left ventricular spike pressure had not changed but ±dp/dtmax decreased by 14%(Control 728.88±38.39 KPa/s, ADM 626.77±25.59 P<0.05); 3.-dp/dtmax decreased by 25% (Control 618.78±39.86 KPa/s. ADM 461.75 ±20.53 p<0.05), T constant strikingly increased by 41% (Control 17±1 ms, ADM 24±2P<0.05); 4. △p/△v increased but no significance statistically. The conclusion is that+dp/dtmax, -dp/dtmax and T constant have changed before advanced heart failure and that T constant,-dp/dtmax are more seensitive than +dp/dtmax. |
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| Keywords: | adriamycin cardiac function |
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