克山病病区粮喂养大鼠对硒酵母硒的相对生物利用度

本研究用克山病病区低硒粮喂养大鼠比较了硒酵母和亚硒酸钠硒的生物利用度。在补硒2和4周时,用心、肝、肾和红细胞硒含量评估,硒酵母硒的生物利用度明显高于亚晒酸钠,说明硒酵母硒比亚硒酸钠硒更有效地存留于组织。当用血小板和肝谷胱甘肽过氧化物酶(GSH_(PX))活性评估时,硒酵母硒的生物利用度在补硒2周时比亚硒酸钠硒低,但在补硒4周时却高于之,表明硒酵母和亚硒酸钠硒均可供GSHP_(PX)合成所利用,但硒酵母恢复GSH_(PX)活性较慢。在停止补硒后,硒酵母维持心和红细胞硒以及肝和血小板GSH_(PX)活性的作用优于亚硒酸钠。

RELATIVE BIOAVAILABILITY OF SELENIUM IN Se-YEAST TO RATS FED ON LOW-Se DIET FROM A KESHAN DISEASE AREA

In the present study the bioavailability of selenium in Se-yeast was compared with that in sodium selenite to rats fed on low-Se diet from a keshan discaes area. The bioavailability of selenium in Se-yeast when estimated by heart, liver kidney and erythrocyte Se contents was significantly greater than that in selenite at wk 2 and 4 of supplement, indicating that selenium in Se-yeast is more cfficiently retained in tissues than selenite selenium. When the criterion used was either platelet or liver glutathione peroxidase (GSH_(?)) activity, the bioavailability was lower for selenium in Se-yeast than for in selenite at wk 2, but higher at wk 4, showing that selenium from both selenite and Se-yeast is clearly available for GSH_(?), synthesis, "although Se-yeast restores GSH_(?) activity more slowly. In addition, the effect of selenium in Se-yeast in maintaining cither Se levels in heart and erythrocyte or GSH_(?) activities in platelets and liver was superior to that of selenite after the selenium supplements were withdrawn.