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| EGFR和Cyclin D1的联合表达预测胶质瘤的放疗敏感性 | |
| 引用本文： | 崔刚,张熙,周乐,屈建强,刘鹏斌.EGFR和Cyclin D1的联合表达预测胶质瘤的放疗敏感性[J].西安交通大学学报(医学版),2008,29(6). |
| 作者姓名： | 崔刚 张熙 周乐 屈建强 刘鹏斌 |
| 作者单位： | 1. 西安交通大学医学院第二附属医院神经外科,陕西西安,710004 2. 西安交通大学医学院第一附属医院神经外科,陕西西安,710061 3. 西安交通大学医学院第二附属医院麻醉科,陕西西安,710004 |
| 基金项目： | 陕西省科技计划基金资助项目 |
| 摘 要： | 目的探讨表皮生长因子受体(EGFR)和Cyclin D1蛋白的表达与胶质瘤放疗敏感性的关系。方法采用免疫组织化学方法检测EGFR和Cyclin D1蛋白在53例不同放疗敏感性胶质瘤和10例正常脑组织中的表达。结果EGFR或Cyclin D1蛋白的表达与胶质瘤的放疗敏感性均无统计学意义(P>0.05)。EGFR和Cyclin D1蛋白的联合表达与胶质瘤的放疗敏感性具有统计学意义(P<0.05)。结论EGFR和Cyclin D1蛋白的联合表达可预测胶质瘤的放疗敏感性。 |
| 关 键 词： | EGFR蛋白 CyclinD1蛋白 脑胶质瘤 放疗敏感性 |
The combined expression of EGFR and Cyclin D1 in predicting the radiosensitivity of glioma |
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| Cui Gang,Zhang Xi,Zhou Le,Qu Jianqiang,Liu Pengbin.The combined expression of EGFR and Cyclin D1 in predicting the radiosensitivity of glioma[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2008,29(6). | |
| Authors: | Cui Gang Zhang Xi Zhou Le Qu Jianqiang Liu Pengbin |
| Institution: | Cui Gang1,Zhang Xi2,Zhou Le1,Qu Jianqiang1,Liu Pengbin3 |
| Abstract: | Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and Cyclin D1 protein and the radiosensitivity of human glioma. Methods The expression of EGFR and Cyclin D1 was detected by SP immunohistochemical technique in brain glioma (n=55) and normal brain tissues (n=10). Results There was no relationship between the expression of EGFR protein and the radiosensitivity of human glioma, so was the Cyclin D1 protein. But the expression of EGFR and Cyclin D1 protein was correlated with the radiosensitivity of human glioma. Conclusion The expression of EGFR and Cyclin D1 might serve as an indicator of radiosensitivity in human glioma. |
| Keywords: | epidermal growth factor receptor (EGFR) protein Cyclin D1 protein glioma radiosensitivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |