急性脑梗死患者血C反应蛋白水平与颈动脉粥样硬化的关系

目的探讨急性脑梗死患者血C反应蛋白(CRP)水平与颈动脉粥样硬化的关系。方法对52例急性脑梗死患者和30例对照组进行观察。采用速率散射比浊法测定血CRP含量;应用美国Acuson Sequoia 521彩色电脑声像仪检测颈动脉内膜-中膜厚度(IMT),观察颈动脉粥样斑块。结果急性脑梗死患者血CRP含量、颈动脉IMT和粥样斑块数较对照组明显增加;血CRP水平与临床神经功能缺损评分、吸烟指数、颈动脉IMT及斑块数呈正相关。结论CRP作为炎性指标可能在促进动脉粥样硬化的发生和发展中起了重要的作用;血CRP水平可作为急性脑梗死患者病情轻重和预后的评价指标。

The relationship between blood CRP concentration and carotid atherosis in patients with acute cerebral infarction

Objective To investigate the relationship between blood C-reactive protein(CRP) concentration and carotid atherosis in patients with acute cerebral infarction.Methods A total of 52 patients with acute cerebral infarction and 30 persons as the controls were included in the study.The concentration of CRP in the blood was measured by rate nephelometry and echocardiographic method.Carotid intima-media thickness(IMT) and carotid plaque were observed by America Acuson Sequoia 521 Computed Sonography.Results The blood CRP concentration,carotid IMT and the number of the carotid pladues were significantly higher in the patients than in the controls.There were positive correlations of the blood CRP concentration with clinical neurological function deficit scale,smoking index,carotid IMT,and number of plaques,respectively.Conclusion CRP is an important index for inflammation at the beginning and progression of atherosis.The blood CRP concentration can be considered as an indicator to evaluate the severity and prognosis of acute cerebral infarction.