原发性骨质疏松症患者骨代谢指标初步研究

目的　探讨原发性骨质疏松症骨吸收和骨形成的生化指标与骨密度关系。方法　分别测定绝经后女性疏松组 (n =2 0 )、绝经后女性正常组 (n =2 0 ) ;中年男性疏松组 (n =2 0 )、中年男性正常组 (n =2 0 )、青年男性正常组 (n =1 5 )外周血钙 (Ca2 +)、磷 (P3- )、血清Ⅰ型前胶原羧基末端前肽 (PICP)、Ⅰ型胶原交联羧基末端肽 (ICTP) ,比较各组差异。结果　各组血清钙、磷测量值无显著性差异 ,绝经后女性疏松组与正常组相比PICP、ICTP值均升高 ,中年男性疏松组与正常组相比PICP值降低、ICTP值升高 ;与青年男性正常组相比 ,PICP值降低、ICTP值无显著性差异。结论　绝经后骨质疏松骨吸收和骨形成均升高 ,但骨吸收大于骨形成 ;中年男性骨质疏松随增龄骨形成生化指标降低 ,骨吸收生化指标增高 ,PICP和ICTP的联合检测有助于骨质疏松的早期诊断。

The primary investigation on the indexes of bone metabolic in primary osteoporosis

Objective The relationship was investigated between BMD(bone mineral density)and biochemical markers of bone resorption and formation in primary osteoporosis.Methods Serum Ca 2 ,P 3- ,PICP and ICTP were determined in postmenopausal osteoporosis group, normal postmenopausal female group;middle-aged male osteoporosis group,normal middle-aged male group,normal young male group,results were compared among groups.Results There was no significant difference on the level of Ca 2 ,P 3- among groups.Both ICTP and PICP increased in postmenopausal osteoporosis group compared with that of control group,PICP decreased while ICTP increased in middle-aged male osteoporosis group compared with that of normal group,but PICP decreased while ICTP had no significant difference compared with that of young male group.Conclusion The bone turn-over in postmenopausal osteoporosis is characterized by high absorption and high formation,but the absorption is over formation. In middle-aged male osteoporosis ,the level of bone formation is low and absorption is high .Measurements of PICP and ICTP is helpful to early osteoporosis diagnosis.