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| 高氧液在新生儿缺血缺氧性疾病中的应用 | |
| 引用本文： | 刘俐,高宁,田代印,李小权,宋健文,周宏艳,王全丽,辛华.高氧液在新生儿缺血缺氧性疾病中的应用[J].西安交通大学学报(医学版),2003,24(6):637-639. |
| 作者姓名： | 刘俐 高宁 田代印 李小权 宋健文 周宏艳 王全丽 辛华 |
| 作者单位： | 1. 西安交通大学第一医院儿科学教研室,陕西西安,710061 2. 成都市妇幼保健院新生儿科,四川成都,610031 3. 西安交通大学医学院统计学教研室,陕西西安,710061 |
| 基金项目： | 科技部创新基金资助项目 (No.0 0c2 62 2 61 1 0 4 64) |
| 摘 要： | 目的 探讨高氧液对新生儿缺血缺氧性疾病治疗的可行性及疗效。方法 采用比色法、血气分析检测 2 0例用高氧液患儿血浆SOD、MDA及血气变化 ,同时以 2 0例未用高氧液患儿作对照 ,观察临床症状、体征改变。结果 用高氧液组PaO2 、SaO2 明显升高 (P <0 .0 1) ,PaCO2 明显下降 (P <0 .0 1) ,同时有pH、HCO3 -、BE下降 ;血浆SOD升高、MDA下降 (P <0 .0 1) ;用高氧液临床症状体征迅速改善 ,有效率 95 % (P <0 .0 5 )。结论 高氧液对治疗新生儿缺血缺氧性疾病尤其是低氧血症有明显效果 |
| 关 键 词： | 高氧液 新生儿 低氧血症 血气分析 超氧化物歧化酶 丙二醛 |
| 文章编号： | 1671-8259(2003)06-0637-03 |
| 修稿时间： | 2003年1月21日 |
A preliminary study on the effect of hyperoxia liquid on neonatal hypoxic-ischemic diseases |
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| Liu Li,Gao Ning,Tian daiyin,Li Xiaoquan,Song Jianwen,Zhou Hongyan,Wang Quanli,Xin Hua.A preliminary study on the effect of hyperoxia liquid on neonatal hypoxic-ischemic diseases[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2003,24(6):637-639. | |
| Authors: | Liu Li Gao Ning Tian daiyin Li Xiaoquan Song Jianwen Zhou Hongyan Wang Quanli Xin Hua |
| Abstract: | Objective To investigate the protective effect of hyperoxia liquid on neonatal hypoxic-ischemic diseases. Methods Forty newborn infants were divided randomly into two groups: control group receiving the routine treatment after hypoxia and ischemia and treatmemt group receiving the routine treatment and infusion of hyperoxia liquid 10 ml·kg -1 after hypoxia and ischemia. Results In treatment group, after giving hyperoxia liquid, PaO 2, SaO 2, and plasma SOD activity were obviously higher than before (P< 0.05). PaO 2, pH, HCO 3 -, BE and plasma MDA content were significantly lower than before (P<0.01). The clinical manifestation of treatment group improved more rapidly than that of control group. Conclusion ① Hyperoxia liquid has obvious protective effects on hypoxic-ischemic disease in newborn infants. ② The application of hyperoxia liquid needs to be improved and developed. |
| Keywords: | hyperoxia liquid newborn anoxemia blood gas analysis superoxide dismutase malondialdehyde |
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