| HLA-DRB1基因多态性与克山病核心家系的关联和连锁分析 |
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| 引用本文： | 王亚萍,牛小麟,董新,魏瑾.HLA-DRB1基因多态性与克山病核心家系的关联和连锁分析[J].西安交通大学学报(医学版),2003,24(4):321-322,347. |
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| 作者姓名： | 王亚萍 牛小麟 董新 魏瑾 |
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| 作者单位： | 西安交通大学第二医院心内科,陕西西安,710004 |
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| 基金项目： | 陕西省科技攻关项目 (No .2 0 0 0K1 4 G1 4 ) |
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| 摘 要： | 目的 探讨克山病与HLA DRB1基因的遗传关系。方法 采用基于单体型相对风险 (HHRR)和传递不平衡检验 (TDT)的方法 ,在 18个克山病患者及 36个双亲中进行DRB1基因多态性的关联和连锁分析。结果 经HHRR和TDT分析 ,克山病患者与DRB1位点DR15相关联和连锁 (χ2 分别为 7.4 0和 12 .2 5 ,P <0 .0 1)。结论 克山病与HLA DRB1 15基因相关联和连锁
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| 关 键 词： | 克山病 HLA-DRB1 关联 连锁 |
| 文章编号： | 1671-8259(2003)04-0321-02 |
Study on the correlation and linkage between HLA-DRB1 gene polymorphism and Keshan disease |
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| Wang Yaping,Niu Xiaolin,Dong Xin,Wei Jin.Study on the correlation and linkage between HLA-DRB1 gene polymorphism and Keshan disease[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2003,24(4):321-322,347. |
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| Authors: | Wang Yaping Niu Xiaolin Dong Xin Wei Jin |
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| Abstract: | Objective To study the genetic relationship between HLA-DRB1 gene polymorphism and Keshan disease (KD) in Chinese. Methods The haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium test (TDT) methods were used to analyze the genetic association and linkage in 18 patients and their parents. Results Significant association ( χ 2=7.40, P<0.01) and linkage ( χ 2=12.25, P<0.01) were between HLA DRB1 allele and KD patients. Conclusion KD is associated and in linkage with HLA DRB1 gene. |
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| Keywords: | Keshan disease HLA DRB1 gene association linkage |
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