维拉帕米及苯肾上腺素对人输卵管的作用

本文分别观察了维拉帕米(Ver)和苯肾上腺素(PE)对离体人输卵管平滑肌的药理作用及与月经周期的关系。结果表明,PE对人输卵管壶腹及峡部肌均产生收缩效应,酚妥拉明可对抗之,在峡部肌,其增生期的PD_2、PA_2值均大于分泌期,环、纵肌之间无差别。Ver抑制人输卵管平滑肌活动并可对抗PE的作用,其分泌期的PD’2值大于增生期。人输卵管的这种药理特性提示,峡部纵肌与环肌的α受体在调节卵运行上是同样重要的。

EFFECTS OF VERAPAMIL AND PHENYLEPHRINE ON HUMAN FALLOPIAN TUBE

The pharmacologic effects of verapamil (Ver) and phenylephrine(PE)on the smooth muscle of the human fallopian tube in vitro and their relationship to the stages of menstrul cycle were observed respectively. The results demonstrated that both the ampulla and isthmus of the human fallopian tube produced a contractive response to PE, which was antagonized by phentolamine. The PD_2 and PA_2 valucs were larger during the proliferative phase than during the secretory phase in the circular and longitudinal muscle of the isthmus. But there was no difference between the circular and longitudinal muscle. Ver supressed the activity of the human fallopian tuba smooth muscle and antagonized the effects of PE.The PD_2~' values were larger during the secretory phase than during the prolifertive phase. These pharmacologic characte risties of the tube indicated that d-adrenoceptor of the longitudinal muscle of the is thmus may be important, like the circular muscle in the regulation of ovum transport.