| 选择性COX-2抑制剂Celecoxib预防大鼠术后腹腔粘连的实验研究 |
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| 引用本文： | 王康,李徐奇,魏光兵,徐昕,平高峰.选择性COX-2抑制剂Celecoxib预防大鼠术后腹腔粘连的实验研究[J].西安交通大学学报(医学版),2010,31(2). |
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| 作者姓名： | 王康 李徐奇 魏光兵 徐昕 平高峰 |
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| 作者单位： | 西安交通大学医学院第一附属医院普外科,陕西西安,710061 |
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| 基金项目： | 陕西省科学技术研究发展计划项目(No.2007K12-02)Supported by the Sci-tech Research Development Project of Shaanxi Province |
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| 摘 要： | 目的 探讨Celecoxib对大鼠术后腹腔粘连形成的预防效果及其机制.方法 80只SD大鼠随机分为5组:接受腹膜擦损术为A组,接受腹膜擦损术+40mg/(kg·d)Celecoxib为B组,接受腹膜擦损术+20mg/(kg·d)Celecoxib为C组,接受腹膜擦损术+透明质酸钠凝胶为H组,仅接受开、关腹操作的假手术为S组.各组随机半数大鼠于术后第8天和15天处死,肉眼评估大鼠一般情况和腹腔粘连程度,免疫组化法检测粘连组织VEGF和CD34.结果 5组大鼠术后粘连程度组间差别具有显著性意义(P<0.01),B组、C组的粘连评分均明显小于H组、A组.VEGF蛋白表达量A组最强,次之分别为H组、C组、B组,S组最弱.CD_(34)表达量A组最强,次之分别为H组、C组、B组,S组最弱.结论 术后短期口服Celecoxib可有效预防大鼠术后腹腔粘连形成,效果优于透明质酸钠凝胶.机制可能与抑制COX-2活性后下调VEGF表达,抑制粘连组织新生血管发生有关.
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| 关 键 词： | 腹腔粘连 环氧合酶-2 血管生成 |
Selective COX-2 inhibitor Celecoxib prevents postoperative abdominal adhesion |
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| WANG Kang,LI Xu-qi,WEI Guang-bing,XU Xin,PING Gao-feng.Selective COX-2 inhibitor Celecoxib prevents postoperative abdominal adhesion[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(2). |
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| Authors: | WANG Kang LI Xu-qi WEI Guang-bing XU Xin PING Gao-feng |
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| Institution: | WANG Kang,LI Xu-qi,WEI Guang-bing,XU Xin,PING Gao-feng(Department of General Surgery,the First Affiliated Hospital,Medical School of Xi an Jiaotong University,Xi an 710061,China) |
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| Abstract: | Objective To determine the preventive effect of Celecoxib on postoperative adhesion formation and its mechanism.Methods We divided80SD rats into5groups: Groups A,B,C,H and S.Rats in Groups A,B,C and H received the operation of peritoneum rubbing to promote adhesion formation.Group S underwent sham operation.Rats in Group B were given Celecoxib of40mg/(kg.d),those in Group C were also given Celecoxib of 20mg/(kg.d),and those in Group H were given sodium hyaluronate(HA) during the operation.On the8th and 15th... |
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| Keywords: | Celecoxib abdominal adhesion cyclooxygenase-2 angiogenesis Celecoxib |
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