| 川芎嗪对脑血管内皮细胞ICAM-1表达的影响 |
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| 引用本文： | 刘勇,许彦钢,林奇.川芎嗪对脑血管内皮细胞ICAM-1表达的影响[J].西安交通大学学报(医学版),1998(2). |
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| 作者姓名： | 刘勇 许彦钢 林奇 |
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| 作者单位： | 西安神经生物学研究中心!西安，710061，陕西省医院神经外科!西安，710061 |
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| 基金项目： | 陕西省自然科学研究项目!94SW27 |
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| 摘 要： | 用细胞培养技术，观察了中药川芎嗪对培养脑微血管内皮细胞间粘附分子（IntercellularAdhesionMolecule－1，ICAM－1）表达的影响。细胞因子肿瘤坏死因子（TNF－α）和脂多糖（LPS）作用24h，使内皮细胞ICAM－1表达上调，预先用中药川芎嗪注射液处理3Omin，再用相同的细胞因子刺激，ICAM-1表达不升高。提示川芎嗪可抑制TNF－α和LPS引起的ICAM－1表达增加。
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| 关 键 词： | ICAM－1 川芎嗪 内皮细胞 |
THE EFFECT OF LITGUSTRAZINE ON THE ICAM-1 EXPRESSION IN CULTURED CEREBROVASCULAR ENDOTHELIAL CELLS |
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| Liu Yong,Xu Yangang,Lin Qi.THE EFFECT OF LITGUSTRAZINE ON THE ICAM-1 EXPRESSION IN CULTURED CEREBROVASCULAR ENDOTHELIAL CELLS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1998(2). |
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| Authors: | Liu Yong Xu Yangang Lin Qi |
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| Institution: | Research Center for Neurobiology |
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| Abstract: | The cerebrovascular endothelial cellculture technique and ELISA method were employedto observe the effect of a traditional Chinese drugLitgustrazine on the intercellular adhesion molecule1 (ICAM-1) expression in the cerebrovascular endothelial cell culture. The results showed that the cytokines TNF-a and lipopolysacharide (LPS) upregulated the ICAM-1 expression by 24h incubation. After 30min pretreatment with Litgustrazine.no increase of the ICAM-1 expression was seen. Theresults suggest that Litgustrazine may inhibit theupregulation effect of the ICAM-1 expression byTNF-a and LPS in the cultured cerebrovascular endothelial cells. |
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| Keywords: | ICAM-1 Litgustrazine endothelium |
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