血清HBV标志物阳性和阴性肾炎患者的临床与病理分析

目的　探讨乙型肝炎病毒 (HBV)感染对肾小球肾炎 (GN)的致病作用。方法　应用免疫组织化学方法 ,检测 2 8例血清HBV阳性和 1 2例HBV阴性组患者肾组织内HBV抗原(HBAg)存在的状况 ,并着重对比了两组患者的临床表现和肾组织病变特征。结果　HBV标志物阳性组HBAg检出率较高 (71 .43 % ) ,肾小球内增生病变较重 ,但统计学处理两组间在临床表现和病变之间均无显著性差异。结论　HBV可能直接感染肾组织细胞导致肾炎的发生。

Analysis of clinicopathologic changes in glomerulonephritis with positive serum HBV markers and negative serum HBV markers

Objective To determine the role of hepatitis B virus (HBV) infection in the pathogenesis of glomerulonephritis.Methods Twenty eight cases of glomerulonephritis with positive serum HBV markers and 12 cases of glomerulonephritis with negative serum HBVmarkers were collected. HBAg was detected by immunohistochemical techniques in these renal tissues. In addition, the clinicopathologic changes of the positive group (G1) and the negative group (G2) were compared.Results Although the positive rate (71.43%) of HBAg in the G1 renal tissues was higher than that of the G2 and the mesangial proliferative changes were more severe in G1 than in G2, there was no significant difference between the clinical manifestations and the pathologic changes of G1 and G2.Conclusion This result suggests that glomerulonephritis may result from direct infection of HBV.