| CD_3AK细胞对白血病细胞的体外杀伤作用 |
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| 引用本文： | 邢佩霓,魏绪仓,杨娣娣,李梅生.CD_3AK细胞对白血病细胞的体外杀伤作用[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 邢佩霓 魏绪仓 杨娣娣 李梅生 |
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| 作者单位： | 陕西省临床医学院血研室 |
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| 摘 要： | ＣＤ３单克隆抗体（ＣＤ３ＭｃＡｂ）对Ｔ细胞具有强烈的丝裂原作用。本文显示将ＣＤ３ＭｃＡｂ联合ＩＬ－２激活的杀伤细胞（ＣＤ３ＡＫ）对人急性白血病新鲜细胞和Ｋ５６２细胞均有明显杀伤作用。正常人ＣＤ３ＡＫ细胞对各型急性白血病杀伤活性无差别；正常人与白血病缓解期的ＣＤ３ＡＫ细胞杀伤力类同，且自体与异体亦无区别；但是，复发期ＣＤ３ＡＫ细胞杀瘤作用明显减弱。
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| 关 键 词： | CD_3AK细胞 白血病细胞 CD_3AK细胞活性 |
THE STUDY OF CD3AK KILLING LEUKEMIACELLS IN VITRO |
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| Xing Peini,Wei Xucang,Yang Didi et al.THE STUDY OF CD3AK KILLING LEUKEMIACELLS IN VITRO[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Xing Peini Wei Xucang Yang Didi |
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| Abstract: | CD3 monoclonal antibody has mitogenetic activity on T cells.This study demonstrated that the antiCD3activited killer cells (CD3AK) have significant killing activity on freshly isolated human acute leukemia cells and cell line K562.There was no significant difference between the killing rate of CD3AK from normal donor on different types of leukemia.The killing activity of CD3AK from patients in remission was similar to normal donor.However from relapse patients ,it was significantly decreased .There was no impact of blood groups on killing activity of CD3AK. |
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| Keywords: | CD3AK leukemia cells CD3AK activity |
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