CLOI遗传多态性与Craves病及桥本氏甲状腺炎的相关性研究

采用淀粉／琼脂糖混合凝胶电泳加碘染色法对110例Craves病（GD）患者及30例桥本氏甲状腺炎（Hashimoto'sthyroiditis，HT）患者与乙二酸酶U（GlyoxalaseI，GLOI）遗传多态性进行了相关性研究。结果显示，GLOI2－1型及GLOI1等位基因与女性的GD呈正相关（RR分别为2．02和1．90，Fisher确切P值分别为0．03和0．02）；GLOI1等位基因亦与伴突眼的GD及HT呈正相关（RR分别为1．78和2．18，Fisher确切P值分别为0．03和0.04）。提示GLOI的遗传多态性与女性GD、体突眼的GD及HT的易感性有关联。可为GD在不同性别中的免疫遗传发病机制与分类以及HT的发病机制研究提供有意义的参考。

ASSOCIATION OF GLO I WITH GRAVES' DISEASEAND HASHIMOTO'S THYROIDITIS

The genetic polymorphism of glyoxalase I (GLO I ) was investigated using mixedstarch/agarose gel electrophoresis and staining withiodine solution in 110 patients with Graves' disease(GD ) and 30 cases of Hashimoto's thyroiditis(HT). These results demonstrated that GLO I 2-1and GOL 11 allele were associated with GD of femalepatients (RR = 2. 02, Fisher P = 0. 03 ; RR = 1. 90,Fisher P =0. 02 respectively) and GLO I1 allele wasassociated with GD with exophthalmos and HT (RR= 1. 78,Fisher P = 0. 03;RR= 2. 18,Fisher P = 0. 04respectively). It was considered that GLO I polymorphism might link to susceptibility gene of GDwith exophthaloms or in female patients and HT.The results might provide reference for the study ofgeneticly pathogenic mechanism of GD and HT.