| 硒对小鼠亚急性阿霉素心肌损害的保护作用 |
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| 引用本文： | 程昕,徐光禄,薛文岚,陈念祖.硒对小鼠亚急性阿霉素心肌损害的保护作用[J].西安交通大学学报(医学版),1992(1). |
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| 作者姓名： | 程昕 徐光禄 薛文岚 陈念祖 |
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| 作者单位： | 西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室 西安 710061 安徽医科大学生物化学教研室，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文以1次剂量阿霉素(ADR 17.5mg/kg ip)引起小鼠亚急性心肌早期病变,探讨硒的保护作用。预先给硒(Se 80μg/kg×10 ip)可防止ADR所致心肌早期损害(D—PAS染色物质显示的细胞膜通透性增加)。这种保护可能与心肌硒水平和谷胱甘肽过氧化物酶活性增高从而降低脂质过氧化产物水平有部分关系。
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| 关 键 词： | 阿霉素 心肌病 小鼠 硒 保护作用 |
PROTECTION OF ADRIAMYCIN-INDUCED SUBACUTE CARDIOMYOPATHY IN MOUSE BY SELENIUM PRETREATMENT |
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| Cheng Xing,Xu Guang-Lu,Xue Wenlan,et al.PROTECTION OF ADRIAMYCIN-INDUCED SUBACUTE CARDIOMYOPATHY IN MOUSE BY SELENIUM PRETREATMENT[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(1). |
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| Authors: | Cheng Xing Xu Guang-Lu Xue Wenlan |
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| Institution: | Research Laboratory of Keshan Disease |
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| Abstract: | The protective effect of selenium (So) on the subacute cardiomyopathy was investigated in the mouse given a single dose of adriamycin (ADR 17. 5mg/kg ip). Se pretreatment (80μg/kg×10 ip) produced protection against the ADR-induced early myocardial damage associated with increased permcability of cell membranes as evidenced by apparent D- PAS (diastase- periodic acid-Schiff) staining material noted in the sarcolemma. The protective effect of Se could be partially explained as the detoxication of lipid peroxides via the action of enhanced cardiac Se-glutathione peroxidase. |
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| Keywords: | adriamycin cardiomyopathy mouse selenium protection |
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