洛美沙星葡萄糖注射液的药效学研究

报道了洛美沙星葡萄糖注射液的体内、体外抗菌活性，并与其口服制剂及环丙沙星注射液进行了比较。结果表明：洛美沙星注射液是一种广谱、高效、作用迅速的抗菌药物，对革兰氏阳性茵的MIC为0．31～20mg／L，对革兰氏阴性菌的MIC为0．005～10mg／L。杀菌实验表明：对金葡菌、大肠杆菌、痢疾杆菌、肺炎杆菌及绿脓杆菌为杀菌作用。抗菌效果基本不受PH、接种菌量和血清蛋白结合的影响。体内效果（ED50）优于口服制剂。体内、外抗菌活性近似于环丙沙星。

PHARMACODYNAMIC STUDY OF LOMEFLOXACIN GLOCOSE INJECTION

The antimicrobial activites in vitro and in vivo of lomefloxacin glucose injection have been reported in this paper, and compared with the lomefloxacin glucose tablets, ciprofloxacin injec-tion. The experiments showed that the injection was a broad spetum, highly active and quickly effected antibiotic. It has a MIC value of 0. 31~20mg/L for gram-positive and 0. 005 ~ 10Tng/L for gram-nega-tive bacteria respectively. The experiments in vivo indicated its bactericidal activities against staphylo-coccus Aureus, Escherichia Coli, Salmonella tyohi,pseudomonas aeruginose and streptocaccus pneumo-niae. The antibiotics activities were not influenced by the pH, the amount of infected bacteria and its combination of serum protein. Both the antimicro-bial actions in vitro and in vivo were similar to ciprofloxacin,s, while better than lomefloxacin tablets,s.