二甲双胍对多囊卵巢综合征伴胰岛素抵抗患者的作用

目的　探讨二甲双胍在多囊卵巢综合征患者伴胰岛素抵抗 (PCOS IR)中的临床作用。方法　 4 6例PCOS IR患者 ,未婚组 2 0例 ,已婚组 2 6例 ,口服二甲双胍 12周 ,采取自身对照法 ,观察试验组用药前、后临床症状、血生殖激素、血糖、胰岛素水平的变化。结果　未婚组 18例恢复排卵性月经 ,2例仍闭经。已婚组 16例恢复排卵 ,4例妊娠 ,10例无效。用药后两组血胰岛素和雄激素水平均降低 ,胰岛素敏感指数上升 ,差异有显著性 (P <0 .0 1)。结论　二甲双胍可有效地改善PCOS患者的胰岛素抵抗 ,降低血雄激素水平并恢复生育功能

The effects of metformin on PCOS-IR

Objective To investigate the clinical effects of metformin on women with polycystic ovary syndrome (PCOS) accompanied by insulin resistance (IR). Methods Forty six patients with PCOS IR were classified into a group of 20 unmarried women and a group of 26 married women, all of whom were administrated with metformin.Clinical symptoms, reproductive hormonal levels, serum insulin and glucose levels were analyzed before and after metformin therapy for 12 weeks by using self controlled study.Results Serum insulin and androgen levels were significantly declined and insulin sensitivity index (ISI) increased ( P <0.01) after metformin administration. Ovulation function recovered in 18 of 20 (90%) women in unmarried group and 16 of 26 (61%) in married group.Conclusion Metformin may effectively improve insulin resistance, reduce serum androgen level, and recover ovulation function in women with PCOS.