杏仁核和扣带回毁损对Ⅰ型精神分裂症患者脑脊液单胺递质的影响

目的　研究立体定向联合毁损杏仁核内侧核群和扣带回前区对Ⅰ型精神分裂症患者脑脊液内单胺类递质的影响 ,探讨手术影响单胺类递质水平及手术治疗精神分裂症的机理。方法　用立体定向技术射频毁损Ⅰ型精神分裂症患者杏仁核内侧核群和扣带回前区 ,用高效液相色谱法 (HLPC)测定手术前后患者脑脊液DA、5 HT、NE的含量 ,对含量的变化进行统计学处理。结果　治疗前不同性别、年龄及病程之间DA、5 HT、NE未见明显差异(P >0 .0 5 ) ;治疗前DA明显高于对照组 ,治疗后DA下降 ,与手术前相比有显著性差异 (P <0 .0 5 ) ;治疗前 5 HT和NE明显低于对照组 ,治疗后升高 ,但仍低于对照组 (P >0 .0 5 )。结论　毁损杏仁核内侧核群和扣带回前区可以使Ⅰ型精神分裂症患者脑脊液内DA水平升高 ,5 HT和NE水平降低 ,这一变化提示调节递质水平可能是手术治疗精神分裂症的途径之一

Influence of media subnucleus of amygdala and front part of callosal gyrus lesion with stereotactic techniques on monoamine transmitters in schizophrene's cerebral spinal fluid

Objective To study the changes of monoamine transmitters in spinal fluid of patients with schizophrenia Ⅰ after damaging media subnucleus of amygdala and front part of callosal gyrus with stereotactic techniques. Methods The different content of DA, 5 HT and NE in spinal fluid was analysised between and postoperative by HLPC. Results There was no difference in different sex, age and course( P >0.05); DA was higher than the contrast and reduced after treatment ( P <0.05); 5 HT increased after treatment; NE was lower than the control before treatment and increased after treatment( P >0.05).Conclusion Lesion of media subnucleus of amygdala and front part of callosal gyrus can increase DA, reduce 5 HT in cerebral spinal fluid of patients with schizophrenia Ⅰ.