| RP-HPLC法测定更昔洛韦血清浓度 |
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| 引用本文： | 王茂义!第一附属医院药剂科,西安,黄猛!第一附属医院药剂科,西安,闫正华!第一附属医院药剂科,西安,苏华!第一附属医院药剂科,西安.RP-HPLC法测定更昔洛韦血清浓度[J].西安交通大学学报(医学版),1999(4). |
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| 作者姓名： | 王茂义!第一附属医院药剂科 西安 黄猛!第一附属医院药剂科 西安 闫正华!第一附属医院药剂科 西安 苏华!第一附属医院药剂科 西安 |
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| 作者单位： | Department of Pharmacy，First Affiliated Hospital |
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| 基金项目： | 陕西省科学技术研究发展计划项目!97K12 - G2 2 |
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| 摘 要： | 为建立 HPL C法测定更昔洛韦血药浓度的方法。采用反相高效液相色谱法 ,以阿昔洛韦为内标 ,流动相为甲醇水溶液 (5∶ 95) ,检测波长为 2 52 nm。结果在 0 .2～ 15μg· ml-1范围内呈良好的线性关系。方法平均回收率为 10 0 .52 % ,RSD日内为 2 .7% ,日间为 2 .5%。说明本方法灵敏度高 ,适合于更昔洛韦的血药浓度测定及药代动力学研究。
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| 关 键 词： | 更昔洛韦 HPLC 血药浓度 |
DETERMINATION OF GANCICLOVIR IN HUMAN SERUM BY RP-HPLC |
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| Wang Maoyi,Huang Meng,Yan Zhenghua et al.DETERMINATION OF GANCICLOVIR IN HUMAN SERUM BY RP-HPLC[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(4). |
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| Authors: | Wang Maoyi Huang Meng Yan Zhenghua |
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| Abstract: | To establish a method for determining ganciclovir in human serum by RP HPLC,a C 18 column was applied to determine ganciclovir in serum.Acyclovir was used as an internal standerd.The mobile phase consisted of water and methanol (95∶5).The detedtor set at 252 nm.The detection ranges were 0.2~15 μg/ml.the average recovery of gancilovir was 100.52% RSD for within day and between days were 2.7% and 2.5%, respectively.The method was precise and convenient. |
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| Keywords: | ganciclovir RP HPLC serum drug concentration |
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